2014
DOI: 10.1186/s40478-014-0143-5
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Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration

Abstract: IntroductionTraumatic brain injury (TBI), a significant cause of death and disability, causes, as in any injury, an acute, innate immune response. A key component in the transition between innate and adaptive immunity is the processing and presentation of antigen by professional antigen presenting cells (APCs). Whether an adaptive immune response to brain injury is beneficial or detrimental is not known. Current efforts to understand the contribution of the immune system after TBI have focused on neuroinflamma… Show more

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Cited by 56 publications
(73 citation statements)
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References 58 publications
(74 reference statements)
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“…Moreover, RTL constructs can block binding and downstream signaling of the cytokine/chemokine, macrophage migration inhibitory factor (MIF) through its CD74 receptor on monocytes and macrophages (Vandenbark et al 2013) (featured on MDLinx.com;). It was previously demonstrated that neurodegeneration after TBI is dependent upon CD74 expression on antigen presenting cells (Tobin et al 2014). RTL treatment of stroke has been shown to inhibit brain-reactive T cells without inducing general immunosuppression (Dziennis et al 2011).…”
Section: Discussionmentioning
confidence: 99%
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“…Moreover, RTL constructs can block binding and downstream signaling of the cytokine/chemokine, macrophage migration inhibitory factor (MIF) through its CD74 receptor on monocytes and macrophages (Vandenbark et al 2013) (featured on MDLinx.com;). It was previously demonstrated that neurodegeneration after TBI is dependent upon CD74 expression on antigen presenting cells (Tobin et al 2014). RTL treatment of stroke has been shown to inhibit brain-reactive T cells without inducing general immunosuppression (Dziennis et al 2011).…”
Section: Discussionmentioning
confidence: 99%
“…Lesion volume was measured as previously described (Basrai et al 2016; Meng et al 2014; Tobin et al 2014). At day 1, 3, 7 or 10 after surgery, mice were transcardially perfused with PBS, followed by 4% paraformaldehyde to fix the brain tissue.…”
Section: Methodsmentioning
confidence: 99%
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“…11,18,19 Briefly, a 2-mm hole was drilled, with dura intact, into the skull over the left parietal cortex (anteroposterior: þ1.5 mm; mediolateral: À1.2 mm). A female luer lock was connected to the hole in the skull.…”
Section: Fpimentioning
confidence: 99%
“…Liver samples were homogenized (three times for 3 seconds), chilled on ice for 5 minutes, and spun at 500 Â g for 5 minutes at 4 C before the addition of 1% Triton X-100, 1% sodium deoxycholate, and 0.1% SDS. Homogenates were mixed by pipetting, sonicated three times for 5 seconds using a Branson sonicator at 50% amplitude, and incubated for 20 minutes on ice.…”
Section: Saa1 Aggregate Analysismentioning
confidence: 99%