Traumatic Brain Injury and Psychiatric Co-Morbidity in the United States

Vaughn, Michael G.; Salas-Wright, Christopher P.; John, Rachel; Holzer, Katherine J.; Qian, Zhengmin; Veeh, Christopher A.

doi:10.1007/s11126-018-9617-0

Cited by 20 publications

(17 citation statements)

References 29 publications

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“…Several studies have demonstrated an increased risk for SUD in adults with a history of TBI (Whelan-Goodinson et al 2009;Corrigan, Bogner, and Holloman 2012). For example, recent data from the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions revealed that TBI was significantly associated with past year SUD (Vaughn et al 2018). McHugo et al assessed the rate and severity of TBI among 295 people in an outpatient mental health facility diagnosed with comorbid mental health disorders and SUD and found that 80% of these patients tested positive for a history of TBI according to the Ohio State University TBI Identification Method (McHugo et al 2017).…”

Section: Clinical History Of Tbi and Susceptibility To Sudmentioning

confidence: 99%

“…Studies that have assessed diagnosis of SUD after history of TBI typically adjust the analysis using confounding factors rather considering these as independent variables. For example, in an adult population, Vaughn et al report a significant correlation of past year TBI with SUD after adjusting for age, sex, race/ethnicity, socioeconomic status (SES), education, and parental history of psychiatric disorders (Vaughn et al 2018). In a population with childhood TBI, Kennedy and colleagues found TBI was associated with problematic alcohol use after adjusting for mother's age and education at birth, social class, self-reported parenting style, and maternal drug use (Kennedy, Heron, and Munafo 2017).…”

Section: 43mentioning

confidence: 99%

“…As mentioned above, the development of anxiety and depression represent the most common neuropsychiatric disorders that TBI patients experience, and similar to the general population, often account for comorbid diagnoses seen in TBI-SUD patients (Vaughn et al 2018;Whelan-Goodinson et al 2009). Just as TBI has been shown to compromise areas of the brain important for the processing of reward and drug-induced euphoria such as NAc, PFC, and VTA, childhood brain injury can also negatively impact areas involved in cognitive and emotional regulation linked to anxiety and depression such as the amygdala and hippocampus (Beauchamp et al 2011).…”

Section: 43mentioning

confidence: 99%

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Brain interrupted: Early life traumatic brain injury and addiction vulnerability

Cannella

McGary

Ramirez

2019

Experimental Neurology

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Recent reports provide evidence for increased risk of substance use disorders (SUD) among patients with a history of early-life traumatic brain injury (TBI). Preclinical research utilizing animal models of TBI have identified injury-induced inflammation, blood-brain barrier permeability, and changes to synapses and neuronal networks within regions of the brain associated with the perception of reward. Importantly, these reward pathway networks are underdeveloped during childhood and adolescence, and early-life TBI pathology may interrupt ongoing maturation. As such, maladaptive changes induced by juvenile brain injury may underlie increased susceptibility to SUD. In this review, we describe the available clinical and preclinical evidence that identifies SUD as a persistent psychiatric consequence of pediatric neurotrauma by discussing 1) the incidence of early-life TBI, 2) how preclinical studies model TBI and SUD, 3) TBI-induced neuropathology and neuroinflammation in the corticostriatal regions of the brain, and 4) the link between childhood or adolescent TBI and addiction in adulthood. In summary, preclinical research utilizes an innovative combination of models of early-life TBI and SUD to recapitulate clinical features and to determine how TBI promotes a risk for the development of SUD. However, causal processes that link TBI and SUD remain unclear. Additional research to identify and therapeutically target underlying mechanisms of aberrant reward pathway development will provide a launching point for TBI and SUD treatment strategies.

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Section: Clinical History Of Tbi and Susceptibility To Sudmentioning

confidence: 99%

Section: 43mentioning

confidence: 99%

Section: 43mentioning

confidence: 99%

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Brain interrupted: Early life traumatic brain injury and addiction vulnerability

Cannella

McGary

Ramirez

2019

Experimental Neurology

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“…Patients with traumatic brain injury (TBI) are at increased risk for psychological disorders including suicide, post-traumatic stress and mood disorders, and for substance abuse; however, data regarding opioid use following TBI in the general population is lacking. [5] Opioids [6] together with benzodiazepines [7] are frequently used in the acute treatment of critically brain-injured patients for the management of intracranial hypertension, to provide analgesia and anxiolysis and to facilitate mechanical ventilation. Opioids and benzodiazepines reduce cerebral metabolic oxygen consumption with minimal effects on cerebral perfusion, which makes them ideal agents for the management of TBI.…”

Section: Introductionmentioning

confidence: 99%

Persistent post-discharge opioid prescribing after traumatic brain injury requiring intensive care unit admission: A cross-sectional study with longitudinal outcome

et al. 2019

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Traumatic brain injury (TBI) is associated with increased risk for psychological and substance use disorders. The study aim is to determine incidence and risk factors for persistent opioid prescription after hospitalization for TBI. Electronic medical records of patients age ≥ 18 admitted to a neuroscience intensive care unit between January 2013 and February 2017 for an intracranial injury were retrospectively reviewed. Primary outcome was opioid use through 12 months post-hospital discharge. A total of 298 patients with complete data were included in the analysis. The prevalence of opioid use among preadmission opioid users was 48 (87%), 36 (69%) and 22 (56%) at 1, 6 and 12-months post-discharge, respectively. In the opioid naïve group, 69 (41%), 24 (23%) and 17 (19%) were prescribed opioids at 1, 6 and 12 months, respectively. Preadmission opioid use (OR 324.8, 95% CI 23.1–16907.5, p = 0.0004) and higher opioid requirements during hospitalization (OR 4.5, 95% CI 1.8–16.3, p = 0.006) were independently associated with an increased risk of being prescribed opioids 12 months post-discharge. These factors may be used to identify and target at-risk patients for intervention.

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“…[ 1 ] Detection of aggressive behavior can be the key to early intervention to improve patients’ quality of life. [ 2 ] Investigating all dimensions of aggressive behavior, such as frequency of attacks, size of aggression, and type (both verbal and physical), can be critical to better understand the correlation between TBI and the development of violent behavior. Few studies have examined the long-term prevalence of aggression among individuals who have experienced a TBI or have illustrated the frequency or type of aggressive episodes.…”

Section: Introductionmentioning

confidence: 99%

The psychometric measures to assess aggressive dimension following traumatic brain injury

et al. 2021

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Background: higher level of aggression and antisocial behavior are frequent following head trauma, due to specific brain alterations. Many tests are used to assess this aspect. A descriptive review was conducted on the main tests used to detect the appearance of aggressive dimensions following traumatic brain injury. Review summary: we searched on PubMed and Web of Science databases and screening references of included studies and review articles for additional citations. From initial 723 publications, only 7 met our search criteria. Findings showed that various psychometric tools are used to assess aggressiveness and its subdomains, following head trauma. Conclusions: further investigation are necessary to clarify whether these tools ensure a reliable diagnosis in order to make an early intervention and reduce violent behavior and its development.

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Traumatic Brain Injury and Psychiatric Co-Morbidity in the United States

Cited by 20 publications

References 29 publications

Brain interrupted: Early life traumatic brain injury and addiction vulnerability

Brain interrupted: Early life traumatic brain injury and addiction vulnerability

Persistent post-discharge opioid prescribing after traumatic brain injury requiring intensive care unit admission: A cross-sectional study with longitudinal outcome

The psychometric measures to assess aggressive dimension following traumatic brain injury

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