Traumatic Brain Injury

Doan, Ninh; Patel, Monaliben; Doan, H T; Janich, Karl

doi:10.4172/2329-9096.1000e120

Cited by 9 publications

(5 citation statements)

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“…We also noted that the postoperative recovery was better in patients with high GCS scores. The evaluation of the patients who underwent surgery revealed that the median GCS scores of those who died and who survived following surgery were 6 (4-12) and 12 (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), respectively; the difference was statistically significant (p < 0.001). Araujo et al (2012) reported that the primary location was the temporoparietal region in 26.5% of the patients.…”

Section: Discussionmentioning

confidence: 99%

“…Not many studies have investigated the incidence rate and social epidemiology of EDHs in Turkey. Reportedly, the majority of cases related to head trauma are a result of urbanization and industrialization not only in Turkey but also globally; traffic accidents, occupational crashes, falls and gunshot wounds are the most common causes of EDH (Eisenberg et al, 1990;Gulsen et al, 2015;Doan et al, 2016;Gurer et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Retrospective clinical evaluation of patients undergoing surgery for acute epidural hematoma

Turkoz¹,

Demirel²

2021

J Exp Clin Med

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We aimed to evaluate mortality-associated factors among patients with acute epidural hematoma due to head trauma. Demographic characteristics, preoperative Glasgow Coma Scale score, epidural hematoma aetiology and radiological findings, accompanying systemic trauma results, hospitalisation duration, sequelae, and mortality features of patients experiencing epidural hematoma between 2014 and 2018 were evaluated. Overall, 79 patients were examined. The most frequent epidural hematoma aetiology was traffic accidents (51.9%), with temporal region being the most common epidural hematoma location (38 [48.2%] patients). Among all, 12 (15.2%) patients died and 67 (84.8%) were discharged. Of them, 57 (85.1%) patients were discharged without and 10 (14.9%) with neurological sequelae. Age>65 years (p=0.001) and low Glasgow Coma Scale score (p<0.05) were significantly associated with higher mortality. Overall mortality rate was 91.7% (p<0.001) in patients with systemic trauma accompanying epidural hematoma, with thoracic (12%) and orthopaedic (9%) trauma being the most common. Cranial injuries included linear fracture, 78.5%; pneumocephalus, 48.1%; cerebral contusion, 44.3%; traumatic subarachnoid haemorrhage, 32.9%; acute subdural hematoma; 26.6%, and collapse fracture, 15%. All cranial injuries except linear fractures were associated with high mortality (p<0.05). Epidural hematoma is associated with high mortality. Aetiology, Glasgow Coma Scale score, cranial pathology, age, and additional trauma are the major predictive mortality-associated factors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Retrospective clinical evaluation of patients undergoing surgery for acute epidural hematoma

Turkoz¹,

Demirel²

2021

J Exp Clin Med

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“…Traumatic brain injury (TBI), a leading cause of morbidity and mortality worldwide, represents a significant socioeconomic problem (Levin, Shum, & Chan, 2014;Maas et al, 2015;Wee, Yang, Lee, Cao, & Chong, 2016;World Health Organization, 2014). In the developed world, the annual incidence of TBI is estimated between 99 to 295 per 100,000 people (Bruns & Hauser, 2003;Doan et al, 2016;Nguyen et al, 2016;Pozzato, Tate, Rosenkoetter, & Cameron, 2019;World Health Organization, 2014), with a projected annual global burden between $98 million USD to $302 million USD (Humphreys, Wood, Phillips, & Macey, 2013). TBI has a highly heterogenous set of long-term consequences, arising from factors relating to its aetiology, pathology, mechanism of damage (i.e., penetrating vs non-penetrating, blast vs non-blast-related) and severity (i.e., mild, moderate or severe) (Maas, 2016).…”

Section: Introductionmentioning

confidence: 99%

A cross-sectional survey of non-specialist Australian audio-vestibular clinical practice for traumatic brain injury and rehabilitation

2023

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Objective: This study explored non-specialist audiological clinical practice in the context of traumatic brain injury (TBI), and whether such practices incorporated considerations of TBI-related complexities pertaining to identification, diagnosis and management of associated auditory and vestibular disturbances. Design: A cross-sectional online survey exploring clinical practice, TBI-related training and information provision was distributed to audiologists across Australia via Audiology Australia and social media. Fifty audiologists, 80% female and 20% male, participated in this study. Years of professional practice ranged from new graduate to more than 20 years of experience. Results: Clear gaps of accuracy in knowledge and practice across all survey domains relating to the identification, diagnosis and management of patients with auditory and/or vestibular deficits following TBI were evident. Further, of the surveyed audiologists working in auditory and vestibular settings, 91% and 86%, respectively, reported not receiving professional development for the diagnosis and management of post-traumatic audio-vestibular deficits. Conclusion: Inadequate resources, equipment availability and TBI-related training may have contributed to the gaps in service provision, influencing audiological management of patients with TBI. A tailored TBI approach to identification, diagnosis and management of post-traumatic auditory and vestibular disturbances is needed.

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“…Injuries and defi cits of the nervous system have devastating effects on millions of people around the world. Estimates indicate that 500,000-700,000 children and 2.5 million adults experience traumatic brain injury each year (1)(2)(3)(4)(5). Annually, more than 795,000 people have strokes in the United States alone (6).…”

Section: Introductionmentioning

confidence: 99%

Adult neural stem cell isolation from whole rat brain and neurosphere culture and differentiation

Ludwig¹,

Patil²

2019

BLL

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Historically, it was thought that neurogenesis ceased by the end of development, but it is currently understood that neurogenesis continues throughout the life of an individual. This continued growth arises from neural stem or progenitor cells (NSCs) located in specifi c regions of the adult brain, including the subventricular zone and the dentate gyrus of the hippocampus. Increased understanding of the nature of these cells and their reaction to environmental stimuli is of paramount importance in the effort to discern their role and potential use in repair following neurological disruption. Neurosphere suspension culture is identifi ed as an effective way of actualizing a self-renewing population of neural stem cells. This study demonstrated that adult rat neural stem cells could be effectively induced to differentiate into cells of astrocytic lineage through exposure to fetal bovine serum (FBS), and that the same population of precursor cells could be induced toward neuronal lineage through exposure to dibutyryl cyclic adenosine monophosphate (dcAMP). There were also observations noted regarding diffi culty inducing cell attachment following enzymatic digestion of neurospheres, and potential effects on various types of assays, including migration assays (Fig. 7, Ref. 31).

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Traumatic Brain Injury

Cited by 9 publications

References 0 publications

Retrospective clinical evaluation of patients undergoing surgery for acute epidural hematoma

Retrospective clinical evaluation of patients undergoing surgery for acute epidural hematoma

A cross-sectional survey of non-specialist Australian audio-vestibular clinical practice for traumatic brain injury and rehabilitation

Adult neural stem cell isolation from whole rat brain and neurosphere culture and differentiation

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