Traumatic brain edema in diffuse and focal injury: cellular or vasogenic?

Marmarou, Anthony; Signoretti, Stefano; Aygok, Gunes A.; Fatouros, Panos P.; Portella, Gina

doi:10.1007/3-211-30714-1_6

Cited by 42 publications

(27 citation statements)

References 6 publications

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“…Indirect measures based on diffusion-weighted imaging have suggested that following TBI without blood-brain barrier (BBB) disruption or with transient BBB disruption, cytotoxic oedema is the dominant cause of persistent brain oedema (Barzo et al 1997;Marmarou et al 2006a). What is lacking, however, is a mechanistic description of the forces driving the flow of water intracellularly.…”

Section: Introductionmentioning

confidence: 99%

Fixed negative charge and the Donnan effect: a description of the driving forces associated with brain tissue swelling and oedema

Elkin

Shaik

Morrison

2010

Phil. Trans. R. Soc. A.

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Cerebral oedema or brain tissue swelling is a significant complication following traumatic brain injury or stroke that can increase the intracranial pressure (ICP) and impair blood flow. Here, we have identified a potential driver of oedema: the negatively charged molecules fixed within cells. This fixed charge density (FCD), once exposed, could increase ICP through the Donnan effect. We have shown that metabolic processes and membrane integrity are required for concealing this FCD as slices of rat cortex swelled immediately (within 30 min) following dissection if treated with 2 deoxyglucose + cyanide (2DG+CN) or Triton X-100. Slices given ample oxygen and glucose, however, did not swell significantly. We also found that dead brain tissue swells and shrinks in response to changes in ionic strength of the bathing medium, which suggests that the Donnan effect is capable of pressurizing and swelling brain tissue. As predicted, a non-ionic osmolyte, 1,2 propanediol, elicited no volume change at 2000 × 10 −3 osmoles l −1 (Osm). Swelling data were well described by triphasic mixture theory with the calculated reference state FCD similar to that measured with a 1,9 dimethylmethylene blue assay. Taken together, these data suggest that intracellular fixed charges may contribute to the driving forces responsible for brain swelling.

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Section: Introductionmentioning

confidence: 99%

Fixed negative charge and the Donnan effect: a description of the driving forces associated with brain tissue swelling and oedema

Elkin

Shaik

Morrison

2010

Phil. Trans. R. Soc. A.

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“…The CES from deceased patients was defined as mortalityrelated CES (mCES). Additionally, it is well known that the brain water content varies with age [29,30]. The difference caused by age is clearly recognizable after the first two years of life [31,32].…”

Section: Methodsmentioning

confidence: 99%

Quantitative analysis of computed tomography images and early detection of cerebral edema for pediatric traumatic brain injury patients: retrospective study

Kim

Yoon

et al. 2014

BMC Medicine

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“…CSF has a key role in spatial compensation because it can be expelled to the spinal theca, the reservoir [56,57]. In the intracranium can be stored 150mL of new volume without a significant increasing of the ICP, this occurs because the venous blood can be derived to the general circulation [50].…”

Section: Intracranial Hypertension (Ich)mentioning

confidence: 99%

Decompressive craniectomy in traumatic brain injury: Quo Vadis?

et al. 2014

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Intracranial hypertension is the leading cause of mortality in patients with cranial injury. Currently the traumatic brain injury is a public health problem worldwide. Decompressive craniectomy emerges as a treatment strategy for patients with refractory intracranial hypertension. The completed surgery requires careful surgical technique and exquisite. We present a review of the literature about the technique.

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Traumatic brain edema in diffuse and focal injury: cellular or vasogenic?

Cited by 42 publications

References 6 publications

Fixed negative charge and the Donnan effect: a description of the driving forces associated with brain tissue swelling and oedema

Fixed negative charge and the Donnan effect: a description of the driving forces associated with brain tissue swelling and oedema

Quantitative analysis of computed tomography images and early detection of cerebral edema for pediatric traumatic brain injury patients: retrospective study

Decompressive craniectomy in traumatic brain injury: Quo Vadis?

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