Traumatic autoplastic transplantation of splenic tissue in man with observations on the late results of splenectomy in six cases

Shaw, A. F. Bernard; Shafi, Adam

doi:10.1002/path.1700450119

Cited by 72 publications

(8 citation statements)

References 10 publications

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“…Conversely, a reduced amount of white pulp has been observed in human splenotic tissue [1,4], and the present results provide experimental support for such clinical findings. Moreover, they also provide the first quantitative data on the morphology of splenotic tissue.…”

Section: Discussionsupporting

confidence: 77%

Differences between the Histology of Normal Spleen and That of Regenerated Ectopically Implanted Splenic Tissue

Felle¹,

Harding²

1988

Eur Surg Res

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The histology of regenerated ectopically implanted spleen (splenotic tissue) from splenectomized rats was compared with that of normal rat spleen. Computer-assisted morphometric analysis revealed significant decreases in both the number and area of splenic nodules in splenotic tissue when compared with normal spleen. It is suggested that the reduction in the amount of white pulp present could explain at least in part the reduced ability of splenotic tissue to deal with infection.

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Section: Discussionsupporting

confidence: 77%

Differences between the Histology of Normal Spleen and That of Regenerated Ectopically Implanted Splenic Tissue

Felle¹,

Harding²

1988

Eur Surg Res

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“…Thoracic splenosis, first reported by Shaw and Shafi in 1937 [6], describes the autotransplantation of splenic tissue into the pleural cavity after splenectomy for traumatic or iatrogenic injury, resulting in multiple nodular implants on the left pleura. Autotransplanted spleens differ from accessory spleens by blood supply, local perforator arteries versus splenic artery respectively [7].…”

Section: Discussionmentioning

confidence: 99%

Intrathoracic splenosis presenting as persistent chest pain

Fukuhara

Tyagi

Yun

et al. 2012

J Cardiothorac Surg

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Thoracic splenosis is a rare entity resulting from splenic and diaphragmatic injury. Patients remain asymptomatic, and surgical intervention is not indicated in the majority of cases. We report a case of a 50-year-old male with a history of splenectomy due to a gunshot wound 30 years previously who presented with vague, progressively worsening chest pain. He was found to have a large intrathoracic splenosis. Unique features of our patient include the presence of symptoms, the significant interval growth of the splenic tissue, and the unprecedented size of the mass, which we believe to be the largest among those previously described.

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“…Thoracic splenosis (TS) was first discovered in an autopsy of a 25-year old male in 1896, 3 and later in six autopsies reported by Shaw and Shafi in 1937. 4 Since then, less than hundred cases have been reported, with its incidence being a mere 18%, 5 most likely owing to the asymptomatic nature of the disease causing it to remain undiagnosed. The disease is seen to have a male predominance, and gradually develops on average 18.8 years after traumatic thoracoabdominal injury, 6 mostly due to gunshots or road traffic accidents.…”

Section: Discussionmentioning

confidence: 99%

Thoracic Splenosis - A necessary differential diagnosis for pleural based nodules with history of thoracoabdominal trauma

et al. 2022

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Thoracic Splenosis (TS) is a rare medical condition, where there is auto-transplantation of the splenic tissue in the thoracic cavity, often leading to pleural based nodules. Our patient is the first ever case of this condition in Pakistan, and underwent extensive diagnostic procedures as well as medical treatments, before receiving the diagnosis of TS. He underwent HRCT for chronic cough that revealed pleural and mediastinal nodules. This coupled with a vague mass in the testes led to the provisional diagnosis of metastasized testicular tumour, and later a diagnosis of pulmonary tuberculosis was made. However, eventually a 99mTc denatured red blood cell scan confirmed the diagnosis of TS. TS is a benign condition, whereas other causes of pleural nodules are relatively malignant, hence its diagnosis is essential in ruling out malignancies. Among the multiple invasive and non-invasive diagnostic modalities, the gold standard remains 99mTc denatured red blood cell scan, which is a sensitive test that provides an accurate diagnosis and bars the need of multiple invasive procedures. doi: https://doi.org/10.12669/pjms.38.3.4563 How to cite this:Mehmood F, Murtaza MM, Ali S, Ashraf A. Thoracic Splenosis - A necessary differential diagnosis for pleural based nodules with history of thoracoabdominal trauma. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.4563 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Traumatic autoplastic transplantation of splenic tissue in man with observations on the late results of splenectomy in six cases

Cited by 72 publications

References 10 publications

Differences between the Histology of Normal Spleen and That of Regenerated Ectopically Implanted Splenic Tissue

Differences between the Histology of Normal Spleen and That of Regenerated Ectopically Implanted Splenic Tissue

Intrathoracic splenosis presenting as persistent chest pain

Thoracic Splenosis - A necessary differential diagnosis for pleural based nodules with history of thoracoabdominal trauma

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