Trauma stimulates the synthesis of Gc-globulin

Abstract

Severe injury results in a prolonged load on the extracellular actin scavenger system; more pronounced in patients who do not survive. Gc-globulin displays characteristics of an acute phase reactant, with supra-normal serum levels 1 week after severe injury. Serial measurements of Gc-globulin after trauma could prove to be a method of early identification of patients with increased risk of mortality.

Vitamin D status after a high dose of cholecalciferol in healthy and burn subjects

“…DBP remained stable while albumin decreased at D7, but was still lower than in healthy subjects. It has been suggested that trauma stimulates synthesis of DBP with supranormal levels one week after injury [32]. At this stage, it is difficult to establish a link between this finding and the present DBP evolution.…”

Gc-Globulin: Roles in Response to Injury

“…Low total and actin-free Gc-globulin concentrations, the latter being an index of residual actin-scavenging capacity, have been demonstrated to be prognostic markers in situations of severe organ damage, such as fulminant hepatic failure (13,14 ), acetaminophen (paracetamol) overdose (15 ), multiple trauma (16 ), and multiple organ failure (8,17 ). Other clinical situations such as septic conditions have also been shown to be associated with low Gc-globulin concentrations and actin complexation (16 ), but the specific role of Gc-globulin has yet to be defined.…”

“…(14,15,17,39,40 Gc-globulin concentration after trauma can be used for early identification of patients with increased risk of lethality. Additional studies revealed that, in polytraumatized patients, concentrations of total and actin-free Gcglobulin are significantly higher in survivors than in nonsurvivors (15,17,40 ).…”

Longitudinal study of vitamin D metabolites after long bone fracture

“…These plasma proteins bind vitamin D metabolites in serum and their concentration modifies free and bioavailable concentrations of these metabolites, with implications for their actions on bone. (14) Concentration of these plasma proteins has long been recognized to fluctuate after trauma and surgery, (15)(16)(17)(18) thus, physiologically relevant free and bioavailable concentrations of vitamin D metabolites might fluctuate postfracture, even if total concentrations do not change. We, therefore, conducted a study to determine kinetics of change in total, free, and bioavailable concentrations of dihydroxylated vitamin D metabolites, and of their parent vitamin D metabolite 25-hydroxyvitamin D (25[OH]D), in humans immediately postlong bone fracture and at 1 and 6 weeks thereafter.…”