Trauma, PTSD, and Substance Use Disorders: Findings From the Australian National Survey of Mental Health and Well-Being

Mills, Katherine L.; Teesson, Maree; Ross, Joanne; Peters, Lorna

doi:10.1176/ajp.2006.163.4.652

Cited by 359 publications

(226 citation statements)

References 0 publications

Supporting

Mentioning

204

Contrasting

Unclassified

Order By: Relevance

“…Along with marijuana and alcohol, opiates are one of the most commonly abused substances among individuals with PTSD, indicating that aberrant endogenous opioid signaling may underlie PTSD (122). In rodents, administration of opioid antagonists increase conditioned fear by enhancing fear acquisition or blocking fear extinction (123–125).…”

Section: Pharmacotherapy Approaches To Fear- and Anxiety-related Disomentioning

confidence: 99%

An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials

Bowers

Ressler

2015

Biological Psychiatry

124

101

View full text Add to dashboard Cite

Posttraumatic stress disorder (PTSD) manifests after exposure to a traumatic event and is characterized by avoidance/numbing, intrusive symptoms and flashbacks, mood and cognitive disruptions, and hyperarousal/reactivity symptoms. These symptoms reflect dysregulation of the fear system likely caused by poor fear inhibition/extinction, increased generalization, and/or enhanced consolidation or acquisition of fear. These phenotypes can be modeled in animal subjects using Pavlovian fear conditioning, allowing investigation of the underlying neurobiology of normative and pathological fear. Pre-clinical studies reveal a number of neurotransmitter systems and circuits critical for aversive learning and memory, which have informed the development of therapies used in human clinical trials. In this review, we discuss the evidence for a number of established and emerging pharmacotherapies and device-based treatments for PTSD that have been developed via a bench to bedside translational model.

show abstract

Section: Pharmacotherapy Approaches To Fear- and Anxiety-related Disomentioning

confidence: 99%

An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials

Bowers

Ressler

2015

Biological Psychiatry

124

101

View full text Add to dashboard Cite

show abstract

“…Among Vietnam veterans, chronic PTSD is associated with less life satisfaction and happiness[12], increased rates of major depression[13], impaired family functioning[12], marital problems[14], occupational disability[11], substance use disorders[15], general medical illnesses[16], and suicide[17] compared with the general population. One sobering study found a 17% mortality rate over six years of follow-up in 51 Vietnam combat veterans, despite intensive treatment at the National Center for PTSD in New Haven (NCPTSD)[18].…”

Section: Introductionmentioning

confidence: 99%

Deep brain stimulation of the basolateral amygdala for treatment-refractory combat post-traumatic stress disorder (PTSD): study protocol for a pilot randomized controlled trial with blinded, staggered onset of stimulation

Koek

Langevin

Krahl

et al. 2014

Trials

View full text Add to dashboard Cite

BackgroundCombat post-traumatic stress disorder (PTSD) involves significant suffering, impairments in social and occupational functioning, substance use and medical comorbidity, and increased mortality from suicide and other causes. Many veterans continue to suffer despite current treatments. Deep brain stimulation (DBS) has shown promise in refractory movement disorders, depression and obsessive-compulsive disorder, with deep brain targets chosen by integration of clinical and neuroimaging literature. The basolateral amygdala (BLn) is an optimal target for high-frequency DBS in PTSD based on neurocircuitry findings from a variety of perspectives. DBS of the BLn was validated in a rat model of PTSD by our group, and limited data from humans support the potential safety and effectiveness of BLn DBS.Methods/DesignWe describe the protocol design for a first-ever Phase I pilot study of bilateral BLn high-frequency DBS for six severely ill, functionally impaired combat veterans with PTSD refractory to conventional treatments. After implantation, patients are monitored for a month with stimulators off. An electroencephalographic (EEG) telemetry session will test safety of stimulation before randomization to staggered-onset, double-blind sham versus active stimulation for two months. Thereafter, patients will undergo an open-label stimulation for a total of 24 months. Primary efficacy outcome is a 30% decrease in the Clinician Administered PTSD Scale (CAPS) total score. Safety outcomes include extensive assessments of psychiatric and neurologic symptoms, psychosocial function, amygdala-specific and general neuropsychological functions, and EEG changes. The protocol requires the veteran to have a cohabiting significant other who is willing to assist in monitoring safety and effect on social functioning. At baseline and after approximately one year of stimulation, trauma script-provoked 18FDG PET metabolic changes in limbic circuitry will also be evaluated.DiscussionWhile the rationale for studying DBS for PTSD is ethically and scientifically justified, the importance of the amygdaloid complex and its connections for a myriad of emotional, perceptual, behavioral, and vegetative functions requires a complex trial design in terms of outcome measures. Knowledge generated from this pilot trial can be used to design future studies to determine the potential of DBS to benefit both veterans and nonveterans suffering from treatment-refractory PTSD.Trial registrationPCC121657, 19 March 2014.Electronic supplementary materialThe online version of this article (doi:10.1186/1745-6215-15-356) contains supplementary material, which is available to authorized users.

show abstract

“…While violence and trauma (CSA) are common experiences of many women, there is little recognition within treatment plans of the connections between trauma, addictions, and mental and physical illnesses (Fellitti, CBC Radio Interview, August 7, 2012). This phenomenon exists despite evidence that childhood sexual abuse is a recognized risk factor for substance abuse among men and women often with a cooccurring diagnosis of PTSD (Blume, Zimmerman, & Tavares, 2006;Mills, Teesson, Ross, & Peters, 2006).…”

Section: Introductionmentioning

confidence: 99%

Nurses’ Perspectives on the Care of Adults with Mental Health Problems and Histories of Childhood Sexual Abuse

Chernomas

Mordoch

2013

Issues in Mental Health Nursing

View full text Add to dashboard Cite

Despite growing awareness and evidence linking childhood sexual abuse (CSA) to numerous ongoing health problems in adulthood, the integration of this knowledge into nursing practice remains inconsistent. This article reports the results of a study that explored nurses' perspectives on, and experiences with, providing care for adults with mental health problems who may also have histories of CSA. Nurses' views underscore the challenges and complexities involved when providing care for this population. The themes of nurses' knowledge and comfort levels, ethical practice, patient care considerations, and system issues are used to discuss nurses' understandings, perspectives, and experiences.

show abstract

Trauma, PTSD, and Substance Use Disorders: Findings From the Australian National Survey of Mental Health and Well-Being

Cited by 359 publications

References 0 publications

An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials

An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials

Deep brain stimulation of the basolateral amygdala for treatment-refractory combat post-traumatic stress disorder (PTSD): study protocol for a pilot randomized controlled trial with blinded, staggered onset of stimulation

Nurses’ Perspectives on the Care of Adults with Mental Health Problems and Histories of Childhood Sexual Abuse

Contact Info

Product

Resources

About