Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas

Pineda, Pedro; Michelsen, H; Rivera, Maria; Lillo, RS; Massardo, Teresa; Araya, Víctor; Sierralta, P; Oviedo, Sandra; Liberman, Claudio

doi:10.4067/s0034-98872000000500007

Cited by 2 publications

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“…Existen dos publicaciones previas con número importante de pacientes, pero enfocados principalmente en la efectividad de la terapia del hipertiroidismo 22,23 . La principal limitación de esta investigación es que se obtienen los datos de manera retrospectiva Enfermedad de Basedow Graves en un hospital universitario -A. Lanas et al desde registros de fichas clínicas, por lo que puede existir algún grado de pérdida de información.…”

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Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario

et al. 2017

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Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario

et al. 2017

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Radioactive iodine therapy for pediatric Graves’ disease: a single-center experience over a 10-year period

Kaplowitz

Jiang

Vaidyanathan

2019

Journal of Pediatric Endocrinology and Metabolism

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IntroductionOnly about 30% of pediatric patients with Graves’ hyperthyroidism achieve remission with medical therapy, and therefore radioactive iodine (RAI) therapy is often used as a definitive treatment. Although the goal of RAI is permanent hypothyroidism, this is not consistently achieved. We conducted a chart review to determine the factors associated with the success of RAI. We also tried to determine optimal follow-up post RAI and if there was an optimal L-thyroxine dose that would normalize the hypothyroid state quickly.MethodsThis is a retrospective chart review of Graves’ patients who underwent RAI between 2008 and 2017. We included age, sex, time from diagnosis, thyroid gland size, total dose of I-131 and dose in μCi/g of thyroid tissue. Patients were grouped based on outcome and analyzed using univariate and multivariate logistic regression. Follow-up thyroid levels post RAI and after starting l-thyroxine were analyzed.ResultsThere were 78 ablations including six repeat ablations. Seventy-three percent became hypothyroid, 23% remained overtly or subclinically hyperthyroid, and 4% were euthyroid. Smaller thyroid size (36.5 vs. 47.4 g; p = 0.037) and higher dose of I-131 (242 vs. 212 μCi/g thyroid tissue; p = 0.013) were associated with a higher likelihood of hypothyroidism. Most patients remained hyperthyroid at 1 month post RAI, but by 3 months the majority became hypothyroid. There was no clear L-thyroxine dose that normalized hypothyroidism quickly.ConclusionsAn I-131 dose close to 250 μCi/g of thyroid tissue has a higher likelihood of achieving hypothyroidism. Testing at 2–3 months after RAI is most helpful to confirm response to RAI.

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Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas

Cited by 2 publications

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Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario

Caracterización de pacientes controlados por enfermedad de Basedow Graves en un hospital universitario

Radioactive iodine therapy for pediatric Graves’ disease: a single-center experience over a 10-year period

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