Tratamiento con linezolid intraventricular más intravenoso en un paciente pediátrico con ventriculitis por Enterococcus faecium resistente a vancomicina

Gómez, Nancy Evelyn Aguilar; Murillo, Sairy Natalia Pérez; Vázquez, Tania María Vargas; Estrada, Jorge Mario Chávez; Saldaña, Napoleón González

doi:10.35366/94420

Cited by 1 publication

(2 citation statements)

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“…Although the use and safety of IT administration for new generation antibiotics are not well established, we administered linezolid intrathecally, which is not done in routine practice, to two patients with VRE meningitis and achieved successful results. Cases that received IT linezolid have been previously reported in the literature 23,24 . IT treatment has become an increasingly popular treatment method, especially in cases of neurosurgery.…”

Section: Discussionmentioning

confidence: 99%

“…Cases that received IT linezolid have been previously reported in the literature. 23,24 IT treatment has become an increasingly popular treatment method, especially in cases of neurosurgery. Empty sterilization was difficult, and no response could be obtained in cases where an antibiotic that did not work well with CNS was used.…”

Section: Demographic Characteristicsmentioning

confidence: 99%

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Experience with enterococcal meningitis/ventriculitis in children

Çay

Alabaz

Gündeşlioglu

et al. 2023

Pediatrics International

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BackgroundEnterococcal infections are increasingly common in hospitalized patients. Enterococcal meningitis/ventriculitis (EMV) is an extremely rare condition of enterococcal infections, occurring particularly in children. This study investigated the clinical and microbiological characteristics, predisposing factors, and prognosis in pediatric patients with EMV.MethodsPediatric patients (<18 years) diagnosed with EMV were retrospectively evaluated over 10 years.ResultsThe study included a total of 25 isolates from 24 patients, median age 23 months (range: 1–136 months). The most common symptoms included vomiting, fever, and headache, with hydrocephalus shunt and preterm birth being the two most common conditions. Commonly associated infections, with central nervous system (CNS) devices as a predisposing factor, were due to external ventricular drainage and ventriculoperitoneal shunts. Two patients with spontaneous meningitis were preterm infant. Of the isolates, 44% were Enterococcus faecalis, 44% E. faecium, and 12% E. gallinarum. Five (20%) isolates were vancomycin resistant. Twelve patients were resistant to anti‐enterococcal antibiotics, including ampicillin, ciprofloxacin, imipenem, teicoplanin, gentamicin, and linezolid (40%, 20%, 8%, 8%, 4%, and 4%, respectively). Enterococcus faecium was more resistant to ampicillin, ciprofloxacin, teicoplanin, and vancomycin than E. faecalis. The median treatment duration was 17 days (interquartile range: 14–26 days).The mortality rate was 8.3% (2/24; both associated with vancomycin resistance).ConclusionsNeurosurgical conditions are the most common predisposing factors for EMV. Preterm birth is an important predisposing factor in children. Because EMV is nonspecific in clinical findings, it should be considered when there is an underlying CNS disorder and empirical treatment should begin in this direction.

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Section: Discussionmentioning

confidence: 99%

Section: Demographic Characteristicsmentioning

confidence: 99%