Laryngoscopy is one of the most painful procedures during balanced general anesthesia, which can cause hemodynamic changes. Opioids are the drugs of choice for analgesics during this process. However, some alternatives offer adequate analgesic control and hemodynamic stability during laryngoscopy, with fewer adverse effects. Our objective was to compare the hemodynamic changes during laryngoscopy between general anesthesia with opioids and opioidfree anesthesia in a Mexican population. We evaluated the information of patients who underwent laparoscopic cholecystectomy under general anesthesia in 2018 at the Nuevo Sanatorio Durango hospital. The Mann-Whitney U test for related samples was used to compare hemodynamic changes during laryngoscopy in 20 patients who received general anesthesia with fentanyl and propofol and 20 patients who received opioid-free anesthesia with dexmedetomidine, lidocaine, and propofol infusion. Changes in hemodynamic parameters during laryngoscopy did not show significant differences between the two comparison groups. Both anesthetic techniques offer similar hemodynamic stability in the Mexican population. The data obtained may generate interest for future studies and allow this technique to be increasingly adopted.