“…5 New techniques and devices have been used to overcome the obstacle posed by lesions with high calcium burden and to increase success rates, such as use of microcatheters, catheters and guidewires that are more rigid and with other conformations, a second guidewire in parallel (buddy wire), anchor ballooning, atheroablative techniques, such as laser or Rotablator™, and other devices, like Tornus®. 9 Historically, patients with ISR present with stable symptoms, with no direct impact on important unfavorable clinical outcomes. Despite the evolution of platforms, polymers and drug elution, stents are not yet free from ISR, which still has an incidence of slightly over 10% in several clinical series.…”