Trastorno depresivo, trastorno de ansiedad y dolor crónico: múltiples manifestaciones de un núcleo fisiopatológico y clínico común

Arango-Dávila, César Augusto; Rincón-Hoyos, Hernán G.

doi:10.1016/j.rcp.2016.10.007

Cited by 27 publications

(7 citation statements)

References 108 publications

(120 reference statements)

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“…Epidemiology studies indicate that prevalence of chronic pain in the general population is 20%–80%, depending on the differences across the studied populations and the methodology of the studies ( 1 ). In patients with chronic pain, depression and anxiety are frequently observed, with prevalence rates ranging from 30% to 50% ( 2 – 4 ). Among people with chronic pain, depression is associated with increased negative thoughts about pain, increased economic burden for patients and their employers, and increased risk of suicide ( 2 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Activation of ventrolateral orbital cortex improves mouse neuropathic pain–induced anxiodepression

Sheng

Cai

et al. 2020

JCI Insight

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Section: Introductionmentioning

confidence: 99%

Activation of ventrolateral orbital cortex improves mouse neuropathic pain–induced anxiodepression

Sheng

Cai

et al. 2020

JCI Insight

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“…Es importante tener en consideración, que el personal oficial ante la presencia de dolor, reposan y toman medicamentos recetadas por el especialista similar a un estudio mencionado por Anderson G (26) . Así mismo, El dolor presente en la espalda es un factor para aumentar la probabilidad de depresión (27) .…”

Section: Discussionunclassified

Low back pain related to anxiety and depression in police officers at a police station in Lima

Bazán¹,

Ventura²

2021

RFMH

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Introducción: El dolor lumbar es un problema que conlleva limitación funcional y puede afectar la salud mental del personal policial. Objetivo: Determinar la asociación el dolor lumbar con ansiedad y depresión en policías de una comisaría en Lima. Métodos: Investigación transversal analítica, con 110 participantes, a partir de un muestro probabilístico, llevado a cabo en la comisaria de Monserrat en Lima. Se utilizó el cuestionario para medir dolor lumbar en el personal policial "CDLPP", que pasó por juicio de expertos y tuvo un alfa de Cronbach de 0,914; para medir ansiedad y depresión se usó el test de Zung. Resultados: Un 75,5% de policías padecen dolor lumbar. Asimismo, se evidencio una relación estadísticamente significativa entre la ansiedad y el dolor lumbar (p=0,028). Pero no se evidenció una asociación estadísticamente significativa entre el dolor lumbar y la depresión (p=0,740). Conclusión: El dolor lumbar se asocia a la ansiedad en los policías una comisaría en Lima. Asimismo, un alto porcentaje de policías padecen dolor lumbar, teniendo en consideración que es un problema de salud pública, podría conllevar a futuro algún tipo de discapacidad afectando su calidad de vida.

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“…Previous studies concluded that FLX was effective to normalize BDNF (16, 17), enhance neurogenesis (18, 19), and inhibit GLU transmission (20, 21). Besides these, the effects of FLX on DA, NE, and 5-HT neurotransmission (22, 23) as well as neuroinflammatory factors (7, 8) were widely verified. Therefore, in this study, we also investigated the relationship between 5-HT levels, TNF-α mRNA expression, and the comorbidity of pain and depression and the effect of FLX on these measures.…”

Section: Introductionmentioning

confidence: 99%

“…Most studies have focused on hypothalamic-pituitary-adrenal (HPA) axis, neurogenesis, various neurotransmitters/neuromodulators, including serotonin (5-HT), norepinephrine (NA), dopamine (DA), glutamate (GLU), and GABA, the endocannabinoid system, brain-neurotrophic factor, opioids, neuroinflammatory factors (5, 6). Among this molecular neurobiology of the comorbidity, neuroinflammatory pathogenic mechanisms (7, 8), and 5-HT deficiency (9, 10) were widely investigated.…”

Section: Introductionmentioning

confidence: 99%

Comorbidity of Pain and Depression in a Lumbar Disc Herniation Model: Biochemical Alterations and the Effects of Fluoxetine

Cai

Lu³

et al. 2019

Front. Neurol.

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Summary of Background Data: Depression is one of the most common comorbidities in patients with chronic low back pain. However, the mechanisms of depression in chronic low back pain patients and the effect of antidepressants on the comorbidity of pain and depression need to be further explored. The establishment of the appropriate animal models and of more effective therapies is critical for this comorbidity. Lumbar disc herniation (LDH) is the most common disease that causes low back pain. The current study examined whether an LDH model shows behavioral and biochemical alterations that are in accordance with the characteristics of the comorbidity of pain and depression and tested the effect of fluoxetine (FLX) on these measures.Objective: The current study examined whether an LDH model showed the behavioral and biochemical alterations that were in accordance with the characteristics of the comorbidity of pain and depression and tested the effect of FLX on these measures.Methods: The LDH animal model was generated by the implantation of the autologous nucleus pulposus on the left L5 nerve root just proximal to the dorsal root ganglion in Wistar rats. Pain intensity was evaluated by mechanical allodynia and thermal hyperalgesia, and changes in depressive behavior were examined by the taste preference and forced swim tests. Hippocampal serotonin (5-HT) levels were measured by liquid chromatography-mass spectrometry, and tumor necrosis factor-α (TNF-α) mRNA was quantified using real-time reverse transcriptase PCR.Results: LDH resulted in chronic pain, which further induced depressive behavior that persisted for 6 weeks after surgery. There were decreased 5-HT concentrations and upregulated TNF-α mRNA levels that were accompanied by behavioral changes. FLX treatment improved depressive behavior and moderately alleviated pain through increased 5-HT concentrations, and inhibited TNF-α mRNA expression.Conclusions: In summary, our studies provide initial evidence that the LDH chronic pain model might serve as a model of the comorbidity of low back pain and depression. The finding that FLX improved depressive behavior and pain through normalized 5-HT concentrations and TNF-α mRNA expression establishes the initial mechanism of the comorbidity of pain and depression.

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Trastorno depresivo, trastorno de ansiedad y dolor crónico: múltiples manifestaciones de un núcleo fisiopatológico y clínico común

Cited by 27 publications

References 108 publications

Activation of ventrolateral orbital cortex improves mouse neuropathic pain–induced anxiodepression

Activation of ventrolateral orbital cortex improves mouse neuropathic pain–induced anxiodepression

Low back pain related to anxiety and depression in police officers at a police station in Lima

Comorbidity of Pain and Depression in a Lumbar Disc Herniation Model: Biochemical Alterations and the Effects of Fluoxetine

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