Trapped in Cristae: Localization and Tracking of Mitochondrial Membrane-Proteins in Living Cells

Abstract

The Hepatitis C Virus (HCV) affects approximately 200 million people throughout the world. About 25% of individuals with HCV will eventually contract chronic liver ailments, such as cirrhosis or liver cancer. Currently, there is no cure for this disease and there are few effective treatments. The HCV RNAdependent RNA polymerase (RdRp) is an enzyme that is presently a target protein for drug discovery because of its importance for viral replication. It is be-