A novel printed antenna with a slotted patch and a defected ground structure (DGS) for dual-band operation is presented. By inserting an I-shaped slot into the patch and defecting the ground plane, triple-mode resonance for achieving dual operation bands, especially an extremely wide bandwidth for the higher band, can be excited. The measured bandwidths are 100 MHz (2.38-2.49 GHz) and 2.94 GHz (3.4-6.34 GHz) for the lower and upper bands, respectively, which agree well with the simulation. The experimental average gains across the two operating bands are 1.0 and 3.9 dBi, respectively, with typical radiation patterns for a patch antenna having a defective ground. The proposed antenna with a compact size of only 22 × 25 mm 2 sufficiently covers performance requirement of the 2.4/5.2/5.8 GHz WLAN and the 3.5/5.5 GHz WiMAX operation systems.