TRapamycin reduces testicular ischemia-reperfusion injury by enhancing autophagy
Zhi Hu,
Qiong Cheng,
Lv Xu
et al.
Abstract:Objectives To confirm the effects of autophagy on testicular ischemia-reperfusion (I/R) injury.
Methods Forty rats were divided into sham group, I/R group, I/R+Rap (rapamycin, autophagy activator) group and I/R+ 3-MA (3-methyl adenine, autophagy inhibitor) group. Before inducing ischemia, rapamycin and 3-MA were intraperitoneally injected into I/R+Rap and I/R+ 3-ma groups, respectively. Subsequently, we then assessed testicular tissue damage. Immunohistochemistry was used to detect Beclin-1 and Caspase-3, whil… Show more
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