Transversely isotropic properties of porcine liver tissue: experiments and constitutive modelling

Chui, Chee-Kong; Kobayashi, Etsuko; Chen, Xian; Hisada, Toshiaki; Sakuma, Ichiro

doi:10.1007/s11517-006-0137-y

Cited by 92 publications

(72 citation statements)

References 18 publications

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“…The experimentally determined range of elastic modulus values using the optical fiber PEP method and QLV fit is 0.1-0.5 KPa for liver, 0.15-0.9 KPa for kidney, and 0.2-8.0 KPa for pancreas. Our results are within the range of previously published elastic modulus values [1,2,[20][21][22][23][24]. Previously reported elastic modulus values vary due to several factors, including the animal model, sample preparation method, and mathematical fit used.…”

Section: Qlv Fitting Resultssupporting

confidence: 87%

Characterization of the mechanical properties of resected porcine organ tissue using optical fiber photoelastic polarimetry

Hudnut

Babaei

Liu

et al. 2017

Biomed. Opt. Express

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Characterizing the mechanical behavior of living tissue presents an interesting challenge because the elasticity varies by eight orders of magnitude, from 50Pa to 5GPa. In the present work, a non-destructive optical fiber photoelastic polarimetry system is used to analyze the mechanical properties of resected samples from porcine liver, kidney, and pancreas. Using a quasi-linear viscoelastic fit, the elastic modulus values of the different organ systems are determined. They are in agreement with previous work. In addition, a histological assessment of compressed and uncompressed tissues confirms that the tissue is not damaged during testing.

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Section: Qlv Fitting Resultssupporting

confidence: 87%

Characterization of the mechanical properties of resected porcine organ tissue using optical fiber photoelastic polarimetry

Hudnut

Babaei

Liu

et al. 2017

Biomed. Opt. Express

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“…Although it is known that the mechanical behavior of the capsule tissue is viscoelastic [30] and transversely isotropic [11], in the concurrent study, only the linear elastic mechanical properties of the capsule were investigated. Since the main objective of this study was to provide a deep understanding of the mechanical response of the fresh human capsule under the axial and transversal tensile and compressive loadings, only the simple mechanical approach was employed.…”

Section: Discussionmentioning

confidence: 99%

“…Sakuma et al [9] calculated the stress-strain diagrams of the porcine capsule tissue under the tensile and unconfined compressive loadings. The same experiments have also been carried out in vitro to measure the mechanical behavior of the bovine [10] and porcine [11] liver capsules under the large strains. The viscoelastic mechanical properties of the liver capsule have also been measured via an optical indentation technique [12].…”

Section: Introductionmentioning

confidence: 99%

An Experimental Study to Measure the Mechanical Properties of the Human Liver

Karimi

Shojaei

2017

Dig Dis

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Background: Since the liver is one of the most important organs of the body that can be injured during trauma, that is, during accidents like car crashes, understanding its mechanical properties is of great interest. Experimental data is needed to address the mechanical properties of the liver to be used for a variety of applications, such as the numerical simulations for medical purposes, including the virtual reality simulators, trauma research, diagnosis objectives, as well as injury biomechanics. However, the data on the mechanical properties of the liver capsule is limited to the animal models or confined to the tensile/compressive loading under single direction. Therefore, this study was aimed at experimentally measuring the axial and transversal mechanical properties of the human liver capsule under both the tensile and compressive loadings. Methods: To do that, 20 human cadavers were autopsied and their liver capsules were excised and histologically analyzed to extract the mean angle of a large fibers population (bundle of the fine collagen fibers). Thereafter, the samples were cut and subjected to a series of axial and transversal tensile/compressive loadings. Results: The results revealed the tensile elastic modulus of 12.16 ± 1.20 (mean ± SD) and 7.17 ± 0.85 kPa under the axial and transversal loadings respectively. Correspondingly, the compressive elastic modulus of 196.54 ± 13.15 and 112.41 ± 8.98 kPa were observed under the axial and transversal loadings respectively. The compressive axial and transversal maximum/failure stress of the capsule were 32.54 and 37.30 times higher than that of the tensile ones respectively. The capsule showed a stiffer behavior under the compressive load compared to the tensile one. In addition, the axial elastic modulus of the capsule was found to be higher than that of the transversal one. Conclusions: The findings of the current study have implications not only for understanding the mechanical properties of the human capsule tissue under tensile/compressive loading, but also for providing unprocessed data for both the doctors and engineers to be used for diagnosis and simulation purposes.

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“…7,8,27,29 These models were developed from experiments with porcine or deer liver tissue. The experimental conditions generally employed low speed loading to simulate the slow deformation rates that would be expected in surgical procedures such as needle biopsy.…”

Section: Introductionmentioning

confidence: 99%

Constitutive Modeling of Rate-Dependent Stress–Strain Behavior of Human Liver in Blunt Impact Loading

Sparks

Dupaix

2008

Ann Biomed Eng

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An understanding of the mechanical deformation behavior of the liver under high strain rate loading conditions could aid in the development of vehicle safety measures to reduce the occurrence of blunt liver injury. The purpose of this study was to develop a constitutive model of the stress-strain behavior of the human liver in blunt impact loading. Experimental stress and strain data was obtained from impact tests of 12 unembalmed human livers using a drop tower technique. A constitutive model previously developed for finite strain behavior of amorphous polymers was adapted to model the observed liver behavior. The elements of the model include a nonlinear spring in parallel with a linear spring and nonlinear dashpot. The model captures three features of liver stress-strain behavior in impact loading: (1) relatively stiff initial modulus, (2) rate-dependent yield or rollover to viscous "flow" behavior, and (3) strain hardening at large strains. Six material properties were used to define the constitutive model. This study represents a novel application of polymer mechanics concepts to understand the rate-dependent large strain behavior of human liver tissue under high strain rate loading. Applications of this research include finite element simulations of injury-producing liver or abdominal impact events.

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Transversely isotropic properties of porcine liver tissue: experiments and constitutive modelling

Cited by 92 publications

References 18 publications

Characterization of the mechanical properties of resected porcine organ tissue using optical fiber photoelastic polarimetry

Characterization of the mechanical properties of resected porcine organ tissue using optical fiber photoelastic polarimetry

An Experimental Study to Measure the Mechanical Properties of the Human Liver

Constitutive Modeling of Rate-Dependent Stress–Strain Behavior of Human Liver in Blunt Impact Loading

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