Transverse Patterning Reveals a Dissociation of Simple and Configural Association Learning Abilities in Rats with 192 IgG-Saporin Lesions of the Nucleus Basalis Magnocellularis

Butt, Allen E.; Bowman, Timothy D.

doi:10.1006/nlme.2001.4013

Cited by 26 publications

(19 citation statements)

References 91 publications

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“…In contrast, NBM lesions caused perseveration during serial reversal discrimination learning; the NBM lesion group required more days and committed more errors in reaching criterion compared with the control group. Together, these results suggest that the NBM plays an important role in mediating cognitive flexibility but that it is not necessary for simple association learning where cognitive flexibility is not required (see also Butt & Bowman, 2002;Butt et al, 2003).…”

Section: Discussionmentioning

confidence: 83%

Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility.

Cabrera¹,

Chavez²,

Corley³

et al. 2006

Behavioral Neuroscience

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The authors tested the hypothesis that the cholinergic nucleus basalis magnocellularis (NBM) is involved in solving problems requiring cognitive flexibility. Rats with 192 IgG-saporin lesions of the NBM were assessed for perseveration (i.e., cognitive inflexibility) in the serial reversal of an operant discrimination and during subsequent extinction testing. It was hypothesized that the NBM lesion and control groups would not differ in the acquisition of the initial, simple discrimination, because this task does not demand cognitive flexibility. In contrast, it was hypothesized that the NBM lesion group would show perseveration during serial reversal and extinction testing. Results generally supported these hypotheses, suggesting that the NBM plays an important role in mediating cognitive flexibility.

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Section: Discussionmentioning

confidence: 83%

Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility.

Cabrera¹,

Chavez²,

Corley³

et al. 2006

Behavioral Neuroscience

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“…Together, these data support the notion that the PPC contributes significantly to the expression of attention-related changes in learning resulting from increases in attentional processing. In addition, the PPC may only be involved when processing resources are sufficiently taxed, as has been postulated for the basal forebrain cholinergic system (Butt & Bowman, 2002;Sarter, Bruno, & Givens, 2003).…”

Section: Discussionmentioning

confidence: 98%

Specific changes in conditioned responding following neurotoxic damage to the posterior parietal cortex.

Bucci¹,

Chess²

2005

Behavioral Neuroscience

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The central nucleus (CN) of the amygdala and basal forebrain cholinergic projections to the posterior parietal cortex (PPC) are involved in regulating changes in attentional processing of conditioned stimuli. In a previous study, lesions of the CN produced a deficit in conditioned orienting behavior (rearing on the hind legs) when a visual stimulus was paired with food. Unconditioned orienting (rearing to nonreinforced presentations of the stimulus) and conditioned food cup behavior were unaffected. The present study examined the contribution of the PPC to attentional orienting behavior. Damage to the PPC did not affect orienting behavior but produced deficits in food cup behavior. These findings help define the specific contributions of the PPC to attentional processing and associative learning.

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“…In contrast, Butt and co-workers have reported that either excitotoxic lesions of the NBM, or selective cholinergic lesions of the NBM using 192IgG-SAP, can significantly impair acquisition of a negative patterning task, without producing impairment on a similar transverse patterning task (Butt and Bowman, 2002;Butt and Hodge, 1997;Butt, Noble, Rogers, and Rea, 2002). There are several possible explanations for the disagreement between these results.…”

Section: Effects On Ca Acquisitionmentioning

confidence: 92%

“…At the completion of DMP testing, rats were trained on an operant configural association (CA) negative patterning task as previously described (Butt, Allen, Arthur, Noble, Rea, and Rogers, 2000;Gibbs, 2005). Training was performed in operant chambers (Med.…”

Section: Ca Trainingmentioning

confidence: 99%

Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy

Gibbs

Johnson

2007

Neurobiology of Learning and Memory

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Abstract192 IgG-saporin (SAP) was used to selectively destroy cholinergic neurons in the rostral basal forebrain (e.g., medial septum (MS) and vertical limb of the diagonal band of Broca (VDB)) and/or the caudal basal forebrain (e.g., nucleus basalis magnocellularis (NBM)) of ovariectomized SpragueDawley rats. The effects of these lesions on two different cognitive tasks, a delayed matching to position (DMP) T-maze task, and a configural association (CA) operant conditioning task, were evaluated and compared. Injecting SAP into either the MS or NBM significantly impaired acquisition of the DMP task. Analysis showed that the effects were due largely to an affect on response patterns adopted by the rats during training, as opposed to an effect on working memory performance. Notably, the impairment in DMP acquisition did not correlate with the degree of cholinergic denervation of the hippocampus. Despite the deficit, most animals eventually learned the task and reached criterion; however by the end of training, controls and animals that received SAP into either the MS or NBM appeared more likely to use an allocentric place strategy to solve the task, whereas animals that received SAP into both the MS and NBM were more likely to use an egocentric response strategy. Cholinergic lesions also produced a small but significant affect on acquisition of the CA task, but only with respect to response time, and only in the SAP-NBM-treated animals. SAP-NBM lesions also produced small but significant impairments in both the number of responses and response time during the acquisition of simple associations, possibly reflecting an effect on alertness or attention. Notably, the effects on CA acquisition were small, and like the effects on DMP acquisition did not correlate with the degree of cholinergic denervation of the hippocampus. We conclude that selective basal forebrain cholinergic lesions produce learning deficits that are task specific, and that cholinergic denervation of either the frontal cortex or hippocampus can affect response patterns and strategy in ways that affect learning, without necessarily reflecting deficits in working memory performance.

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Transverse Patterning Reveals a Dissociation of Simple and Configural Association Learning Abilities in Rats with 192 IgG-Saporin Lesions of the Nucleus Basalis Magnocellularis

Cited by 26 publications

References 91 publications

Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility.

Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility.

Specific changes in conditioned responding following neurotoxic damage to the posterior parietal cortex.

Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy

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