Transverse Myelitis: Unusual Sequelae of Neonatal Group B Streptococcus Disease

Transverse myelitis (TM) includes a pathobiologically heterogeneous syndrome characterized by acute or subacute spinal cord dysfunction resulting in paresis, a sensory level, and autonomic (bladder, bowel, and sexual) impairment below the level of the lesion. Etiologies for TM can be broadly classified as parainfectious, paraneoplastic, drug/toxin-induced, systemic autoimmune disorders, and acquired demyelinating diseases. We discuss the clinical evaluation, workup, and acute and long-term management of patients with TM. Additionally, we briefly discuss various disease entities that may cause TM and their salient distinguishing features, as well as disorders that may mimic TM.

show abstract

“…Bacteria reported to cause PITM 155,195,[201][202][203][204][205][206][207][208][209][210][211][212][213][214] are listed in Box 5.…”

Section: Vogt-koyanagi-harada Syndromementioning

confidence: 99%

Transverse Myelitis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Furthermore, a case series of 8 term infants with GBS meningitis and ischemic stroke on MRI found 2 recognizable patterns of injury, deep perforator arterial infarction, and more superficial cortical injury [ 10 , 11 ]. Case reports of neuroimaging in term infants with GBS meningitis have also found severe global cerebral vasculopathy and transverse myelitis [ 12 , 13 ]. In preterm infants, inflammatory cytokines associated with infection increase the permeability of the blood–brain barrier and have an adverse effect on myelin and myelin-producing cells, resulting in periventricular leukomalacia, a condition strongly associated with neurodisability [ 14 , 15 ].…”

mentioning

confidence: 99%