Transverse myelitis associated with cat-scratch disease in an adult

Pickerill, R. G.

doi:10.1001/jama.246.24.2840

Cited by 10 publications

(3 citation statements)

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“…Arteritis and direct bacterial invasion have both been the proposed mechanisms of cat-scratch encephalitis (Carithers & Margileth, 1991;Selby & Walker, 1979). Two cases of transverse myelitis have also been reported (Pickerill & Milder, 1981;Salgado & Weisse, 2000). 3.5.3d.…”

Section: 53c Neurological Complicationsmentioning

confidence: 99%

Reemergence of Established Pathogens in the 21st Century

Fong¹,

Drlica²

2003

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Section: 53c Neurological Complicationsmentioning

confidence: 99%

Reemergence of Established Pathogens in the 21st Century

Fong¹,

Drlica²

2003

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“…A myelitis resulting in a Brown-Séquard syndrome has also been described with cat-scratch dis-ease. 70 Lyme disease, the result of infection with Borrelia burgdorferi, may also result in a myelopathy. 71…”

Section: Tuberculosismentioning

confidence: 99%

Infectious Myelopathies

Berger¹,

Sabet²

2002

Semin Neurol

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Although infectious myelopathies are rare, timely and accurate diagnosis is essential to improving outcome. There are a number of organisms that may cause infectious myelopathies, including human immunodeficiency virus (HIV), human T-cell lymphotropic virus type I (HTLV-I), herpesviruses, enteroviruses, Treponema pallidum, Mycobacterium tuberculosis, fungi, and parasites. Vacuolar myelopathy, the most common form of spinal cord disease in HIV-infected individuals, is underrecognized clinically. The failure to diagnose this condition is generally a consequence of the attribution of the lower extremity weakness and paresthesias to general debility and concomitant peripheral neuropathy. Tropical spastic paraparesis or HTLV-I-associated myelopathy involves the pyramidal tracts, chiefly at the thoracic level, and results in spastic lower extremity weakness and a spastic bladder. The herpesviruses (varicella-zoster, herpes simplex type 2, cytomegalovirus) and the enteroviruses cause myelitis. Prior to the development of antibiotics, syphilis was the most frequent infectious cause of spinal cord disease. In light of the broad spectrum of pathogens that may affect the spinal cord and the variegate fashion in which these disorders may present, the physician must always consider an infectious etiology in the differential diagnosis for the patient presenting with myelopathy. This review addresses the infectious myelopathies by microorganism.

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“…Central nervous system (CNS) involvement can occur in conjunction with many of these disorders. Neurologic sequelae of cat scratch disease include encephalopathy, myelopathy, meningitis, cerebral arteritis, optic neuritis, and radiculopathy (2,4,21,27,32). Cerebral bacillary angiomatosis has been reported in human immunodeficiency virus (HIV)-infected patients (34), and aseptic meningitis has been described in association with relapsing B. henselae bacteremia (22).…”

mentioning

confidence: 99%

Infection of Fetal Feline Brain Cells in Culture withBartonella henselae

et al. 2001

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Bartonella henselae is known to cause central nervous system (CNS) disease in humans, and neurological signs have been observed in experimentally infected cats. However, the pathogenesis of CNS disease remains unclear. This study was undertaken to determine whether B. henselae infects feline fetal brain cells in vitro. Microglial-cell-and astrocyte-enriched cultures were inoculated with B. henselae. Giménez staining identified bacterial organisms within microglial cells by day 7 postinoculation. The viability of the intracellular bacteria was demonstrated by incubating cultures with gentamicin and plating cell lysate on agar. Electron microscopy identified intracellular organisms with characteristic Bartonella morphology but identified no ultrastructural abnormalities within infected microglial cells. No evidence of infection was seen in Bartonella-inoculated astrocyte cultures. These findings suggest a role for microglia in the pathogenesis of B. henselae-associated neurological disease.

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Transverse myelitis associated with cat-scratch disease in an adult

Cited by 10 publications

References 0 publications

Reemergence of Established Pathogens in the 21st Century

Reemergence of Established Pathogens in the 21st Century

Infectious Myelopathies

Infection of Fetal Feline Brain Cells in Culture withBartonella henselae

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