Transverse Electronic Transport in Double-Stranded DNA Nucleotides

Jauregui, Luis A.; Salazar-Salinas, Karim; Seminario, Jorge M.

doi:10.1021/jp808790j

Cited by 21 publications

(26 citation statements)

References 61 publications

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“…This result confirms the study by Jauregui and coworkers that the ds DNAs ͑A-T͒ and ͑C-G͒ exhibit different electronic characteristics due to their different density of states. 17 The Fermi levels associated with the four bases, ds DNAs ͑A-T͒ and …”

Section: Methodsmentioning

confidence: 99%

Polysilicon Wire for the Detection of Label-Free DNA

Wu¹,

Hsu²,

Hsu

et al. 2010

J. Electrochem. Soc.

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In this paper, we report the use of polysilicon ͑poly-Si͒ wire for label-free DNA sequence detection. Both single-strained ͑ss͒ homopolymers, polyadenine ͓poly͑A͔͒, polythymine ͓poly͑T͔͒, polycytosine ͓poly͑C͔͒, and polyguanine ͓poly͑G͔͒, and doublestranded ͑ds͒ heteropolymers ͑one homopolymer with its complement homopolymer͒, ͑A-T͒ ͓poly͑A-T͔͒ and ͑C-G͒ ͓poly͑C-G͔͒, were detected. These polymers, with different lengths and concentrations, were dropped onto the poly-Si wire surface, and then the currents flowing through the poly-Si wire channel were determined. The absolute value of the amount of current change ⌬I in the channel for ss homopolymers with fixed length and fixed concentration is as follows: poly͑T͒ Ͼ poly͑C͒ Ͼ poly͑G͒ Ͼ poly͑A͒. For ds heteropolymers, it was observed that poly͑A-T͒ has a ⌬I that is higher than that of poly͑C-G͒. This study also showed that the poly-Si wire is useful for detecting single-and multiple-base changes in the ss homopolymers as well as singleand multiple-matched-pair changes in ds heteropolymers. A single-pair mismatch in ds poly͑C-G͒ was also investigated in this work.The determination of DNA sequences has long been a topic of intensive research in biotechnology and medical diagnostics because the genetic information carried by an organism is inscribed in its DNA. In addition, the measurement of DNA conductivity, hybridization, and melting by electronic means has drawn a great deal of attention in recent years due to its possible applications in molecular electronics. 1-3 A DNA sequence is typically determined by using radiochemical, enzymatic, and fluorescent techniques, 4,5 in which labels or reagents are added into the molecules that are being tested and detected. These techniques are usually time-consuming, expensive, and complicated to implement. Therefore, label-free DNA detection methods such as cyclic voltammetry and chronopotentiometry were developed. 6-9 However, these label-free methods are of wet type, where the sensor has to be immersed in the solution being tested, and hence the selectivity as well as the detection limit of the sensor is influenced by the thermal drift of the electrolyte solution. [10][11][12] As a result of the rapid progress in semiconductor fabrication technologies, many semiconductor/nanodevices and measurement tools have been developed either to measure the electrical properties of DNA or to detect DNA. [13][14][15][16][17][18][19] For example, Storm and his coworkers used nanogap junctions to measure the electrical resistance of hybridized and denatured DNA molecules. 13 Zwolak and Di Ventra used nanopores to observe the different chemical structures of the four different bases of DNA and proved that each of the four bases of DNA carries a unique electronic and chemical structure. 14 This result was later confirmed by Xu and his co-workers by measuring the current flowing through DNA with a scanning probe microscope ͑SPM͒. 16 However, the aforementioned nanopore device is difficult to fabricate and the SPM is very expensive.At the same...

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Section: Methodsmentioning

confidence: 99%

Polysilicon Wire for the Detection of Label-Free DNA

Wu¹,

Hsu²,

Hsu

et al. 2010

J. Electrochem. Soc.

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“…Nosotros aplicamos estas técnicas para predecir las características electrónicas de un sistema, el cual puede ser el mismo fenómeno a detectar, como la secuencia de nucleótidos erradas en el DNA; así como moléculas e interfaces de los componentes electrónicos del nano-sensor. Para la lectura de secuencias de nucleótidos, nuestras investigaciones concluyen que las características eléctricas son identificables durante la medición transversal de la corriente, simulando el paso vertical y controlado del DNA dentro de un poro con nano-electrodos de oro en su interior [32,33]. Errores de complementariedad de los nucleótidos como AA, CC, GG, TT resultan menos conductivos que los pares complementarios de nucleótidos, siendo el más conductor el par CT [33].…”

Section: Transporte De Electronesunclassified

La Nanoelectrónica y la Electrónica Molecular

2018

Rev. ECIPeru

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La Nanoelectrónica y la Electrónica Molecular Jorge M. Seminario and Karim Salazar Department of Chemical Engineering Department of Electrical and Computer Engineering Department of Materials Science and Engineering Texas A&M University College Station, Texas, USA E-mail: seminario@tamu.edu Recibido el 10 de diciembre del 2016; aceptado el 18 de diciembre del 2016 DOI: https://doi.org/10.33017/RevECIPeru2016.0007/ Resumen La nanotecnología ofrece herramientas para el diseño de sensores automatizados capaces de neutralizar agentes tóxicos mediante el desarrollo de operaciones lógicas y comunicación de la información. El uso de componentes moleculares en la fabricación de nanosensores, resulta ventajoso debido a la alta capacidad de transmisión de información, eficiencia y rapidez de las operaciones. El objetivo es desarrollar nanosensores inteligentes mediante operadores lógicos en base a la interacción del potencial electrostático molecular y el transporte de información mediante señales vibracionales. El presente trabajo muestra resultados preliminares basados en principios básicos de la materia, como la mecánica cuántica, mecánica molecular y dinámica molecular. Las cascadas de compuertas lógicas moleculares operarían a través de señales basadas en el potencial electrostático molecular. Permitiendo la realización de funciones matemáticas de todo tipo mediante arreglos de compuertas lógicas. Siendo los valores positivo y negativo del potencial electrostático señales de entrada y salida de una compuerta lógica. Finalmente, la información contenida en la salida seria transportada mediante fluctuaciones de los modos vibracionales a través de moléculas lineales en el rango de terahertz (THz). Descriptores: Nanotecnología, nano-sensores programables, compuertas lógicas moleculares, potenciales electrostáticas moleculares, transporte eléctrico, señales vibracionales. Abstract Nanotechnology offers tools for the design of automated sensors capable of neutralizing toxic agents through the development of logical operations and communication of information. The use of molecular components in the manufacture of nanosensors is advantageous because of the high capacity of information transmission, efficiency and speed of operations. The goal is to develop intelligent nanosensors using logical operators based on the molecular electrostatic potential interactions and the transport of information through vibrational signals. The current work shows preliminary results based on basic principles of matter, such as quantum mechanics, molecular mechanics and molecular dynamics. The cascades of molecular gates would operate through signals based on molecular electrostatic potential. These logical gate arrays will allow us to perform all kind of mathematical functions. The positive and negative values of the molecular electrostatic potential will be the input and output signals of a logic gate. Finally, the information contained in the output will be transported through linear molecules by fluctuations of vibrational modes in the terahertz (THz) range. Keywords: Nanotechnology, programmable nano-sensors, logic gates, molecular electrostatic potential, electron transport, vibrational signals.

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“…In Ref. , they calculated the transverse current through double‐stranded DNA nucleotide and showed that the current–voltage features provide signatures for DNA sequencing. Also electron‐tunneling properties of different base pairs (G‐C, A‐T, G‐T, and 2AA‐T) have been investigated by Lee and Sankey .…”

Section: Introductionmentioning

confidence: 99%

DNA sequencing with titanium nitride electrodes

Chen

2013

Int. J. Quantum Chem

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We construct a hydrogen‐bond based metal–molecule–metal junction, which contains two identical “reader” molecules, one single DNA base as a bridged molecule, and two titanium nitride electrodes. Hydrogen bonds are formed between “reader” molecules and DNA base, whereas titanium–sulfur bonds are formed between “reader” molecules and titanium nitride electrodes. We perform electronic structure calculations for both the bare bridged molecule and the full metal–molecule–metal system. The projected density of states shows that when the molecule is connected to the titanium nitride electrode, the energy levels of the bridged molecule are shifted, with an indirect effect on the hydrogen bonds. This is similar to the case for a gold electrode but with a more pronounced effect. We also calculate the current–voltage characteristics for the molecular junctions containing each DNA base. Results show that titanium nitride as an electrode can generate distinct conductance for each DNA base, providing an alternative electrode for DNA sequencing. © 2013 Wiley Periodicals, Inc.

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Transverse Electronic Transport in Double-Stranded DNA Nucleotides

Cited by 21 publications

References 61 publications

Polysilicon Wire for the Detection of Label-Free DNA

Polysilicon Wire for the Detection of Label-Free DNA

La Nanoelectrónica y la Electrónica Molecular

DNA sequencing with titanium nitride electrodes

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