Transversal and longitudinal lecithin-sphingomyelin ratios in amniotic and lung fluids of fetal lambs

Rethmeier, H.B.; Egberts, H. J. A.

doi:10.1016/0002-9378(75)90055-1

Cited by 9 publications

(9 citation statements)

References 7 publications

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“…However, the amniotic L/S ratio was not very useful in lambs (22,29). A relationship between the increase of L/S ratio and increase of fetal age was hardly present, but the slope of such a curve was rather flat; a clear bend could not be noticed.…”

Section: Introductionmentioning

confidence: 95%

“…The L/S ratio in lung fluid was studied in the eleven lambs delivered by Caesarian section and in two stillbirths, of which the longitudinal results are published (29).…”

Section: Methodsmentioning

confidence: 99%

“…The L/S ratio was determined in lung fluid of lambs delivered by Caesarian section as well as in the last fraction of lung fluid from intra-uterine chronically tracheal-intubated lambs (29). In figure 4 the L/S ratio is plotted against the fetal age.…”

Section: Lecithin-sphingomyelin Ratiomentioning

confidence: 99%

“…A relationship between the increase of L/S ratio and increase of fetal age was hardly present, but the slope of such a curve was rather flat; a clear bend could not be noticed. The curve of the L/S ratio of lung fluid, however, was much steeper and in longitudinal studies we noticed a breaking point (29). Considering these results, we decided to use the L/S ratio of lung fluid as a prenatal maturity index in lambs.…”

Section: Introductionmentioning

confidence: 99%

“…The fetal lung produces considerable amounts of fluid (4,29) in which phospholipids are noticeable (2,17,29). Most of this fluid -as far as the lamb is concerned (1) -will be swallowed, but probably some will leak into the amniotic cavity.…”

Section: Introductionmentioning

confidence: 99%

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Pressure Volume Curves of Lamb Lungs and the Lecithin-Sphingomyelin Ratios of Lung Fluid

Egberts¹,

Rethmeier²

1975

Neonatology

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Pressure-volume curves were made of lungs from non-distressed, from asphyxiated and from distressed lambs. The curves of the non-distressed animals differed from the curves of the asphyxiated and of the distressed group. Eleven stability indices were calculated and the summation of these in situ surfactant characteristics was used for individual respiratory distress syndrome diagnosis. Low values (< 2) of lecithin/sphingomyelin (L/S) ratios in lung fluid were found before the 130th day of gestation, but a steep increase of the L/S ratio was present after that period. Postnatal RDS was found in low L/S ratio cases, whereas normal lung stability was noticed in animals with L/S ratios > 2. It is concluded that the prenatal L/S ratio in lung fluid of lambs is of predicting value in RDS experiments and fits well with lung stability characteristics.

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Section: Introductionmentioning

confidence: 95%

“…The L/S ratio in lung fluid was studied in the eleven lambs delivered by Caesarian section and in two stillbirths, of which the longitudinal results are published (29).…”

Section: Methodsmentioning

confidence: 99%

Section: Lecithin-sphingomyelin Ratiomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%