Transvaginal sonography as a screening method for ovarian cancer

Higgins, RV; Nagell, JR Van; Donaldson, ES; Gallion, HH; Pavlik, EJ; Endicott, B; Woods, CH

doi:10.1016/0020-7292(90)90928-e

Cited by 10 publications

(10 citation statements)

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“…Ovarian cancer remains a killer disease, because the majority of patients present at an advanced stage when curative medical intervention is no longer a realizable goal. Recent studies have suggested that not only is ovarian cancer screening possible, but may also result in a survival benefit for those women who have a cancer detected by screening (1–8) .…”

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confidence: 99%

An analysis of ovarian tumor diameter and survival

Stratton¹,

Pharoah²,

Tidy³

et al. 2000

Int J Gynecol Cancer

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Residual disease following primary debulking surgery is a recognized prognostic factor in ovarian cancer. Few studies have looked at the effect of initial ovarian tumor diameter on survival. As larger tumors are more likely to be detected by ultrasound, this information may be important in determining a survival benefit in screen-detected cancers. We reviewed the case notes and pathology of 168 consecutive cases of primary debulking surgery in epithelial ovarian cancer. We examined the influence of ovarian tumor diameter on survival and its relationship to CA125 levels and stage. For the purposes of analyses, we divided subjects into two groups: those with tumors < 6 cm and those with tumors > 6 cm. There were significant differences between the groups, with smaller tumors having more advanced stage disease compared to larger tumors (chi23 = 15.7, P = 0.0013) The median survival for tumors less than or equal to 6 cm was 17months (95% confidence interval [95% CI], 12 to 22), while for tumors greater than 6cm, the median survival was 36 months (95% CI, 13 to 59; logrank test = 8.61, P = 0.003). However, stage is also an important predictor of survival, and in a multivariate analysis, tumor size was not found to be an independent prognostic factor. There was no significant difference between the groups for CA125 levels. As larger diameter ovaries are more likely to be detected by ultrasound, it may be that screen-detected ovarian cancers will show a survival benefit simply because they detect a subset of ovarian cancers that are associated with a better prognosis.

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mentioning

confidence: 99%

An analysis of ovarian tumor diameter and survival

Stratton¹,

Pharoah²,

Tidy³

et al. 2000

Int J Gynecol Cancer

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“…Point-of-care ultrasonography has since expanded to include procedural, diagnostic, and screening applications in a wide range of specialties [18][19][20][21][22][23]. Procedural guidance as in central line placement [24,25], diagnostic assessment as in the Focused Assessment with Sonography in Trauma (FAST) [26][27][28], thoracic cavitary ultrasonography to assess for pleural effusion, pneumothorax, or pneumonia [29,30], verification of tracheal airway placement [18], musculoskeletal diagnosis and treatment [14], cardiovascular applications [11,12,31], and gynecological screening [32,33] are now all commonplace in the clinical arena. New applications of ultrasound are presently being explored in the realms of thermal tumor ablation, hemorrhage control, nanotechnology, fracture healing, and noncontact wound therapy [34][35][36][37][38][39].…”

Section: Overview Of General Ultrasound Applications In Hemodynamic Amentioning

confidence: 99%

Clinician-performed ultrasound in hemodynamic and cardiac assessment: a synopsis of current indications and limitations

Kelly

Esteve

Papadimos

et al. 2015

Eur J Trauma Emerg Surg

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Accurate hemodynamic and intravascular volume status assessment is essential in the diagnostic and therapeutic management of critically ill patients. Over the last two decades, a number of technological advances were translated into a variety of minimally invasive or non-invasive hemodynamic monitoring modalities. Despite the promise of less invasive technologies, the quality, reliability, reproducibility, and generalizability of resultant hemodynamic and intravascular volume status data have been lacking. Since its formal introduction, ultrasound technology has provided the medical community with a more standardized, higher quality, broadly applicable, and reproducible method of accomplishing the above-mentioned objectives. With the advent of portable, hand-carried devices, the importance of sonography in hemodynamic and volume status assessment became clear. From basic venous collapsibility and global cardiac assessment to more complex tasks such as the assessment of cardiac flow and tissue Doppler signals, the number of real-life indications for sonology continues to increase. This review will provide an outline of the essential ultrasound applications in hemodynamic and volume status assessment, focusing on evidence-based uses and indications.

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“…Vaginal ultrasound can detect masses as small as 2 mm in diameter, that is, at a stage at which they may not be palpated during physical examination. 66,67 Two analytic methods have been applied to improve the discrimination between malignant and benign lesions: (1) application of a morphology index based on ovarian volume, cyst wall thickness, and septal structure; and (2) use of color-flow Doppler, which can reliably distinguish the lower impedance to blood flow of ovarian neoplasms. 68,69 CA-125 is a glycoprotein that is shed into the blood by malignant cells, most commonly of ovarian epithelial origin.…”

Section: Ovarian Cancermentioning

confidence: 99%