Transtoracal puncture biopsy of vital volumes of mediastinal tumors under pet/ct navigation

Abstract

The aim of the study is to determine the diagnostic efficiency of transthoracic puncture biopsy of vital subvolumes of mediastinal tumors based on PET + CT navigation. The study involved 110 patients with benign, malignant. metastatic tumors and with non-neoplastic pathology of mediastinum. Consecutive CT + PET-CT examination of patients, combination of PET and CT images with reference to CT anatomical landmarks were conducted. The vital subvolume for biopsy is determined by the contours of the hyperfixation foci of the radiopharmaceutical on the background of CT tumor structure. The needle is inserted under CT control in real time. Diagnostic efficiency of transthoracic puncture biopsy of vital subvolumes of mediastinal tumors under PET/CT navigation: sensitivity – 92.6% (95% confidence interval [CI], 92.1-93.1%), specificity – 76.2% (95 % CI, 75.7-76.7%), accuracy – 86.4% (95% CI, 85.9-86.9%), efficiency – 57.3% (95% CI, 56.8-57,8%).