Transthyretin-related amyloid in a saphenous vein. Histological diagnosis in a patient undergoing coronary artery bypass surgery

Farci, Fabiola; Martino, Andrea De; Pratali, Stefano; Bortolotti, Uberto; Pucci, Angela

doi:10.1016/j.carpath.2019.03.004

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2023

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“… 6 A case report has been made of ATTR amyloid accumulation in eccentric intimal thickening of a saphenous vein graft harvested for coronary artery bypass grafting surgery. 7 This observation reinforces our hypothesis that amyloid toxicity plays a role in the development of vascular disease, including arteriosclerosis and vasculopathy. Further longitudinal investigations are needed to determine the pathophysiological role of transthyretin amyloid in the development of coronary artery disease and to demonstrate the effect of ATTR-targeting therapies on plaque regression.…”

Section: Discussionsupporting

confidence: 85%