Transthyretin cardiac amyloidosis in Saudi Arabia and the Middle East: insights, projected prevalence and practical applications

Mohty, Dania; Omer, Mohamed H.; Ahmad, Omar; Alayary, Islam; Alzahrani, Talal; Damy, Thibaud; Fadel, Bahaa

doi:10.3389/fcvm.2023.1265681

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2024

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“…Distinguishing these two types of CA is pivotal, as their clinical course and management are vastly different [6]. Currently, the prevalence of CA in the Middle East is noticeably underrepresented in literature and the condition remains underdiagnosed, with the vast majority of patients going undiagnosed [7].…”

Section: Introductionmentioning

confidence: 99%

Challenges and Uncertainties in the Diagnosis of Cardiac Amyloidosis: A Case Report

Ibrahim,

Gaffar Mohammed,

Elmasharaf

et al. 2024

Cureus

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Amyloidosis is the condition when starch-like misfolded proteins form insoluble fibrils that deposit in tissues and cause dysfunction. Cardiac amyloidosis occurs due to the deposition of amyloid fibrils at the cardiac level and is an important cause of heart failure. This case reveals a patient with significant heart failure and arrhythmia, which later on turned out to be caused by cardiac amyloidosis. While regarded as a rare disease in practice, in retrospect, there are a lot of signs and imaging indicators, particularly in echocardiography that warrant an investigation of cardiac amyloidosis. In this case review, red flags in echocardiography that should endorse further testing for underlying cardiac amyloidosis are highlighted.

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Section: Introductionmentioning

confidence: 99%