Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database

Feng, Mengling; McSparron, Jakob I.; Dang, Trung Kien; Stone, David J.; Roberts, David H.; Schwartzstein, Richard M.; Vieillard‐Baron, Antoine; Celi, Leo Anthony

doi:10.1007/s00134-018-5208-7

Cited by 175 publications

(171 citation statements)

References 40 publications

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“…Using the estimated propensity scores as weights, an inverse probabilities weighting (IPW) model was used to generate a weighted cohort [17]. A Cox proportional hazards regression was then performed to adjusted propensity score.…”

Section: Discussionmentioning

confidence: 99%

Association of Preadmission Metformin Exposure and Outcomes in Acute Kidney Injury Patients with Type 2 Diabetes in Intensive Care Unit: a Cohort Study

Zheng¹,

Wen²,

Chen³

et al. 2020

Preprint

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Background: Acute kidney injury (AKI) occurred in more than half of ICU patients. The effective prevention and therapies strategy of AKI remains limited. This study is to assess AKI mortality among diabetes patients with or without preadmission prescriptions for metformin. Methods: We included AKI patients with type 2 diabetes in Medical Information Mart for Intensive Care (MIMIC)-III database. 30-day mortality, neutrophil-to-lymphocyte ratio, and length of stay (LOS) in the hospital were compared between those with and without preoperative prescriptions. The statistical approaches included multivariate regression, propensity score analysis and an inverse probability‑weighting model to ensure the robustness of our findings. Results: In total, 4328 AKI patients with type 2 diabetes (998 in preadmission metformin usage group and 3330 in no preadmission metformin usage) were included in the analysis. The overall 30-day mortality was 14.2% (613/4328). There was 15.7% (523/3330) and 9.0% (90/998) of 30-day mortality in no preadmission metformin usage and preadmission metformin usage group, respectively. In the main analysis, preadmission metformin usage was associated with a 37% lower of 30-day mortality (HR=0.63,95% CI:0.50-0.80, p<0.0001) in inverse probability‑weighting model. Conclusions: This cohort study suggested that preadmission metformin usage may be associated with reduced risk-adjusted mortality in AKI patients with type 2 diabetes. Further randomized controlled trials are needed.

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Section: Discussionmentioning

confidence: 99%

Association of Preadmission Metformin Exposure and Outcomes in Acute Kidney Injury Patients with Type 2 Diabetes in Intensive Care Unit: a Cohort Study

Zheng¹,

Wen²,

Chen³

et al. 2020

Preprint

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“…The widely used MIMIC (Medical Information Mart for Intensive Care) critical care database has been developed for more than a decade contains comprehensive clinical data of patients admitted to the Beth Israel Deaconess Medical Centre in Boston, Massachusetts 10,11 . For many years, it has been the only freely accessible database in critical care medicine, and it supports a broad range of research areas, as evidenced by many publications [12][13][14][15] . Building upon the success of MIMIC-III, Philips Healthcare developed a multi-centre intensive care unit database called the eICU Collaborative Research Database 16 .…”

Section: Background and Summarymentioning

confidence: 99%

PIC, a paediatric-specific intensive care database

Zeng

et al. 2020

Sci Data

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PIC (Paediatric Intensive Care) is a large paediatric-specific, single-centre, bilingual database comprising information relating to children admitted to critical care units at a large children's hospital in China. The database is deidentified and includes vital sign measurements, medications, laboratory measurements, fluid balance, diagnostic codes, length of hospital stays, survival data, and more. The data are publicly available after registration, which includes completion of a training course on research with human subjects and signing of a data use agreement mandating responsible handling of the data and adherence to the principle of collaborative research. Although the PIC can be considered an extension of the widely used MIMIC (Medical Information Mart for Intensive Care) database in the field of paediatric critical care, it has many unique characteristics and can support database-based academic and industrial applications such as machine learning algorithms, clinical decision support tools, quality improvement initiatives, and international data sharing.

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“…Because all the data is deidenti ed, no informed consent is required. In recent years, some high-quality papers using this database's data have been published [30]. In this study, data presented were extracted by author Chen, who completed the National Institutes of Health (NIH) Web-based training course and the Protecting Human Research Participants examination (No.…”

Section: Sources Of Datamentioning

confidence: 99%

Is Monitoring for Phosphate a Necessary Measure in Critical Ill Patients ?

Chen

Luo

et al. 2020

Preprint

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Background: In recent years, some studies have shown that hyperphosphatemia and hypophosphatemia are associated with high mortality in intensive care unit (ICU) patients. Based on this, we speculated that the abnormalities of serum phosphate when patients enter the ICU had an adverse effect on the mortality of ICU patients and conducted our study.Methods: For our retrospective cohort study, we collected the data from a publicly accessible critical care database. We selected adult patients admitted to ICU with some inclusion criteria. And we extracted a large number of clinical variables. Using multivariate Cox regression and other statistical methods, we assessed the association between serum phosphate and primary endpoints.Results: Of 27131 eligible patients, the patients with hyperphosphatemia or hypophosphatemia had poorer clinical outcomes. After adjustment for potential confounders, there was no significant association between abnormalities phosphate and 28 or 90-day ICU mortality. Nevertheless, at the medical intensive care unit, hyperphosphatemia was associated with a 37% higher risk of 28-day mortality or a 25% higher risk of 90-day mortality.Conclusion: After adjustment for potential confounders, hypophosphatemia and hyperphosphatemia at ICU admission were not the independent risk factors of 28 or 90-day mortality for general ICU patients. However, hyperphosphatemia at admission increased the risk of 28 or 90-day mortality among patients admitted to the medical intensive care unit.

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Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database

Abstract: In a general population of critically ill patients with sepsis, use of TTE is associated with an improvement in 28-day mortality.

Cited by 175 publications

References 40 publications

Association of Preadmission Metformin Exposure and Outcomes in Acute Kidney Injury Patients with Type 2 Diabetes in Intensive Care Unit: a Cohort Study

Association of Preadmission Metformin Exposure and Outcomes in Acute Kidney Injury Patients with Type 2 Diabetes in Intensive Care Unit: a Cohort Study

PIC, a paediatric-specific intensive care database

Is Monitoring for Phosphate a Necessary Measure in Critical Ill Patients ?

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Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database

Abstract: In a general population of critically ill patients with sepsis, use of TTE is associated with an improvement in 28-day mortality.

Cited by 175 publications

References 40 publications

Association of Preadmission Metformin Exposure and Outcomes in Acute Kidney Injury Patients with Type 2 Diabetes in Intensive Care Unit: a Cohort Study

Association of Preadmission Metformin Exposure and Outcomes in Acute Kidney Injury Patients with Type 2 Diabetes in Intensive Care Unit: a Cohort Study

PIC, a paediatric-specific intensive care database

Is&nbsp;Monitoring for Phosphate&nbsp;a Necessary Measure in Critical Ill Patients ?

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Is Monitoring for Phosphate a Necessary Measure in Critical Ill Patients ?