Reliable assessment of ventricular function is an essential for management of patients with heart disease. Noninvasive echocardiographic evaluation is indispensable for repeated assessment of ventricular function in the clinical setting. Alterations of left and right ventricular geometry and loading conditions are the property of congenital heart disease; therefore, quantitative assessment of ventricular function is technically challenging. Systolic ventricular function is pump activity for the generation of an adequate cardiac output with filling pressure as low as possible. A wide variety of different echocardiographic parameters and indices are developed for the assessment of systolic ventricular function; however, no single parameter adequately provides all the necessary information. One should integrate information from different parameters to comprehensively describe systolic function. Echocardiographic assessment of diastolic function is based on Doppler method of mitral inflow and the pulmonary veins with supplemental assessment by tissue Doppler, strain, and strain rate. Although several indices are available, no single indices adequately evaluate diastolic function. Therefore, a comprehensive examination is mandatory as well as in systolic ventricular function. This chapter will discuss traditional and newer echocardiographic techniques for the evaluation of ventricular function and, in addition, vascular function in patients with congenital heart disease.