Materials and Methods Relevant studies were identified by searching the following data sources-Medline via Ovid, Embase, Cochrane Library and using the 'related citation' search tool in PubMed. Reference lists from identified studies were also scanned to identify any other relevant studies. The following inclusion criteria were used: (i) studies comparing patients undergoing transfemoral or transradial approach (ii) comparison of outcome, benefit and risk between the two approaches. Meta analyses and systemic review were also included in this review. Duplicate publications were excluded. The search strategy identified 155 citations. 25 studies were duplicates and after screening of titles and abstracts, a further 83 studies were included. Of the 83 studies selected, 47 fulfilled out eligibility criteria and are included in this systematic review.