Transposition of the great arteries with posterior aorta, anterior pulmonary artery, subpulmonary conus and fibrous continuity between aortic and atrioventricular valves

Praagh, Richard Van; Pérez-Treviño, C; López-Cuéllar, M; Baker, Frances W.; Zuberbuhler, James R.; Quero, M; Pérez, Valentín Viqueira; Moreno, Felipe; Praagh, Stella Van

doi:10.1016/0002-9149(71)90049-x

Cited by 196 publications

(64 citation statements)

References 14 publications

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“…We strongly support the view of Van Praagh et al (1971) Heart 4 showed anatomically corrected malposition associated with a primitive ventricle. Anatomically corrected malposition is rare, and has not, as far as we are aware, been reported previously in association with a primitive ventricle.…”

Section: Atrial Anatomy In Left Juxtaposition Of Auriclessupporting

confidence: 87%

Left juxtaposition of the auricles with l-position of the aorta. Report of 6 cases.

Allwork¹,

Urban²,

Anderson³

1977

Heart

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Six hearts are described in whichjuxtaposition of the auricles to the left of thegreat arteries (leftjuxtaposition) was associated with I-position of the aorta. Atrial anatomy was abnormal but constant; the os of the right auricle occupied the expected site of the atrial septum, producing posterior and inferior displacement of this structure. This is of importance since the os could be mistaken for a defect of the atrial septum, while the displacement of actual defects is of significance to any intended catheterisation procedure including atrial septostomy. Five of the hearts showed atrioventricular concordance while the other specimen was an example of pritmtive ventricle with a right-sided outlet chamber. The ventriculoarterial connection in this latter case was normal, with 1-malposition (anatomically corrected malposition). Ventriculoarterial connections in the other hearts were transposition in 3, single aortic trunk with pulmonary atresia in 1, and an intermediate between double outlet right ventricle and transposition in the other. These cases confirm the observation that iuxtaposition of the auricles is associated with severe cyanotic congenital heart disease.

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Section: Atrial Anatomy In Left Juxtaposition Of Auriclessupporting

confidence: 87%

Left juxtaposition of the auricles with l-position of the aorta. Report of 6 cases.

Allwork¹,

Urban²,

Anderson³

1977

Heart

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“…However, whether such malformations grow consistently into the definitive form of TCA has not been proved. In our experiment, the definitive form of complete TGA was found in the embryos sacrificed on the 12th d. i., the anatomy of which was compatible with the common and simple definition of TGA, i.e., that the aorta originates from the RV and the PA from the LV (Van Praagh et al, 1971b). This insists that chick is available for an animal model to study morphogenesis of TGA.…”

Section: Discussionsupporting

confidence: 83%

Conotruncal Anomalies Induced in Chick Embryos by 2 MeV Neutron Radiation

Kawamura

1984

Congenital Anomalies

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Radiation of 2 MeV neutrons was used to induce conotruncal anomalies experimentally in chick. White leghorn eggs were exposed to a single dose of neutrons ranging from 50 to 250 rads at various stages of the development. Cardiovascular anomalies were found in 209 (40%) of 526 treated embryos; conotruncal anomalies (81/209 or 39%), simple VSD (56/209 or 27%), isolated aortic arch anomalies (69/209 or 33%) and others (3/209 or 1%). The conotruncal anomalies were induced at considerably high incidences by exposures during the 3rd day of incubation and the highest incidence was 74% in the cases malformed by 220 rads. The types of conotruncal anomalies observed were as follows: VSD with pulmonary overriding (52 cases), VSD with aortic overriding (11 cases), DORV (10 cases), truncus arteriosus (6 cases) and complete TGA (2 cases). Sixty (74%) of these cases had aortic hypoplasia, constituting coarctation or interruption complex similar to that seen in man. It is generally thought that the experimental production of complete TGA in chick appears to be impossible when utilizing ordinary teratogenic means. However, neutron radiation could induce this peculiar anomaly in chick. Key words: neutron radiation, complete TGA in chick, coarctation complex, conotruncal anomalies In a previous paper (Kawamura et al., 1980), it was reported that radiation of 2 megaelectron volt (MeV) neutrons proved to have a significant teratogenic effect on the developing chick heart and could induce the coarctaion type of ventricular septa1 defect (coarctation type of VSD) very similar to that seen in man. The present experiment has revealed that this method induced many other specific anomalies involving the conotruncal region of the heart.The purpose of this presentation is to analyze the spectrum of conotruncal anomalies in chick induced by this method. MATERIALS AND METHODSWhite leghorn eggs were exposed to a single dose of 2 MeV neutrons generated by a Van de Graaff

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“…The latter arrangement is also called normal relations, albeit with discordant ventriculoarterial connections. 11,12 The variations encountered were described using words but then analyzed in light of the commonly used alphanumeric classifications. Results are given in absolute numbers or in percentages.…”

Section: Methodsmentioning

confidence: 99%

Anatomic Variability in Coronary Arterial Distribution With Regard to the Arterial Switch Procedure

et al. 2002

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Background-We investigated the coronary arterial origins and course and the position of the great arteries in hearts with discordant ventriculoarterial connections. At the same time, we sought to evaluate the practicality of alphanumeric classifications in accounting for surgically relevant features of the coronary arteries. Methods and Results-We studied 200 postmortem hearts, noting the patterns of coronary arterial branching, the vertical and horizontal location of the arterial orifices within the aortic sinuses, the course of the proximal coronary arteries in relation to the aortic wall, and the relations of the great arteries and their respective commissures. All hearts examined had concordant atrioventricular and discordant ventriculoarterial connections. We found 7 of the 8 predicted patterns for sinusal origin of the 3 major coronary arteries and identified 5 different positions of the arterial trunks relative to each other. A correlation was found between less frequent relationships of the arterial trunks and unusual patterns of coronary arterial branching, as well as with mismatch between the valvar commissures. Conclusions-The surgically relevant features of the coronary arteries in hearts with discordant ventriculoarterial connections are best described rather than classified. Correlations exist between certain, less frequent relations of the great arteries and unusual patterns of branching of the coronary arteries. The presence of unusual great arterial positions should alert the surgeon to potentially complicated arrangements of the origin and distribution of the coronary arteries.

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Transposition of the great arteries with posterior aorta, anterior pulmonary artery, subpulmonary conus and fibrous continuity between aortic and atrioventricular valves

Cited by 196 publications

References 14 publications

Left juxtaposition of the auricles with l-position of the aorta. Report of 6 cases.

Left juxtaposition of the auricles with l-position of the aorta. Report of 6 cases.

Conotruncal Anomalies Induced in Chick Embryos by 2 MeV Neutron Radiation

Anatomic Variability in Coronary Arterial Distribution With Regard to the Arterial Switch Procedure

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