“…Transpositions have a multifactorial aetiology with both genetic and environmental factors playing a role, 7,8 with the following factors all having been cited as having causative roles in transpositions: genetics, ectopic position of tooth bud, crowding, mechanical interference, early loss of deciduous tooth, over retention of deciduous teeth, trauma to deciduous teeth and cysts or local pathology. 2,5,[8][9][10][11] An increased incidence of transpositions has been reported in patients with other dental anomalies, which supports genetics having a role in the aetiology of transpositions. 2,3,7 Compared to the general population, a four-to ten-fold increase in transpositions has been reported in patients with hypodontia, illustrated in Figure 2, and an eight-to sixteen-fold increase in patients with peg-shaped lateral incisors.…”