2023
DOI: 10.3390/molecules28031151
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Transporter-Mediated Drug Delivery

Abstract: Transmembrane transport of small organic and inorganic molecules is one of the cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier (SLC) proteins form the largest, albeit very diverse, superfamily with over 400 members. It was recognized early on that xenobiotics can directly interact with SLCs and that this interaction can fundamentally determine their efficacy, including bioavailability and intertissue distribution. Apart from the well-established prodrug strategy, the chemi… Show more

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Cited by 28 publications
(31 citation statements)
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References 524 publications
(644 reference statements)
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“…On the other hand, our GO term analysis also clearly demonstrated significant downregulation of transmembrane transporter coding RNAs in vimentin‐positive IBC‐NSTs; SLC transporter plays a very important role in the uptake of chemotherapeutic agents into carcinoma cells 56–60 . The KEGG pathway analysis also clearly demonstrated ABC transporter coding RNAs being significantly upregulated in vimentin‐positive IBC‐NSTs, and these transporters are known to play very important roles in the efflux chemotherapeutic agents from carcinoma cells 56–60 .…”
Section: Discussionmentioning
confidence: 61%
See 1 more Smart Citation
“…On the other hand, our GO term analysis also clearly demonstrated significant downregulation of transmembrane transporter coding RNAs in vimentin‐positive IBC‐NSTs; SLC transporter plays a very important role in the uptake of chemotherapeutic agents into carcinoma cells 56–60 . The KEGG pathway analysis also clearly demonstrated ABC transporter coding RNAs being significantly upregulated in vimentin‐positive IBC‐NSTs, and these transporters are known to play very important roles in the efflux chemotherapeutic agents from carcinoma cells 56–60 .…”
Section: Discussionmentioning
confidence: 61%
“…[52][53][54][55] On the other hand, our GO term analysis also clearly demonstrated significant downregulation of transmembrane transporter coding RNAs in vimentinpositive IBC-NSTs; SLC transporter plays a very important role in the uptake of chemotherapeutic agents into carcinoma cells. [56][57][58][59][60] The KEGG pathway analysis also clearly demonstrated ABC transporter coding RNAs being significantly upregulated in vimentin-positive IBC-NSTs, and these transporters are known to play very important roles in the efflux chemotherapeutic agents from carcinoma cells. [56][57][58][59][60] Since transmembrane transport coding RNAs regulate drug absorption and excretion in cancer cells, the pharmacodynamic activity in vimentin-positive IBC-NSTs may be lower than that in vimentin-negative IBC-NSTs, so that they may have a greater propensity to develop drug resistance to anticancer agents than vimentin-negative IBC-NSTs, which could also contribute to the heightened malignant potential of vimentinpositive IBC-NSTs.…”
Section: Mitotic Cytokinesismentioning
confidence: 93%
“…Brent & Fawcett 69 reported the unexpected nding that in E8.5 embryos or younger rat embryos up to 95% of the amino acids in tissues of the embryo were derived from metabolism of maternal proteins. Later in development placental transfer of amino acids is a prominent feature of placental function in both human and rodents 36,37,42,43 .…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, glucose-/galactose-based nanoconjugate formulation enhances the delivery of anti-BACE1 siRNA and 3D6 antibody fragments (3D6-Fab) in the transgenic mouse model of Alzheimer's disease through the GLUT1-mediated uptake pathway. 118 Nanoconjugation provides a new direction in the field of protein aggregation. Therefore, nanoconjugation could provide highly efficient therapeutic strategies for protein misfolding diseases.…”
Section: Potential Nano-osmolyte Aggregation Inhibitorsmentioning
confidence: 99%
“…However, amino acids conjugated with liposomes containing drugs interact more effectively with the solute carrier (SLC) proteins to deliver the drugs into the carcinoma cell lines. Moreover, glucose-/galactose-based nanoconjugate formulation enhances the delivery of anti-BACE1 siRNA and 3D6 antibody fragments (3D6-Fab) in the transgenic mouse model of Alzheimer’s disease through the GLUT1-mediated uptake pathway …”
Section: Potential Nano-osmolyte Aggregation Inhibitorsmentioning
confidence: 99%