We show that the phenomenology of isospin effects on heavy ion reactions at intermediate energies (few AGeV range) is extremely rich and can allow a "direct" study of the covariant structure of the isovector interaction in the hadron medium. We work within a relativistic transport frame, beyond a cascade picture, consistently derived from effective Lagrangians, where isospin effects are accounted for in the mean field and collision terms. Rather sensitive observables are proposed from collective flows ("differential" flows) and from pion/kaon production (π − /π + , K 0 /K + yields). For the latter point relevant nonequilibrium effects are stressed. The possibility of the transition to a mixed hadron-quark phase, at high baryon and isospin density, is finally suggested. Some signatures could come from an expected "neutron trapping" effect.