Transport Phenomena

Bird, R. B.; Stewart, W. E.; Lightfoot, E. N.; Spalding, D. B.

doi:10.1115/1.3641697

Cited by 982 publications

(1,461 citation statements)

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“…The diffusivity of the nanoCipro can be estimated by applying the Stokes-Einstein equation (eqn. 3) [33]. Here, D AB is the diffusion coefficient of nanoCipro in dichloromethane, k is Boltzmann's constant, T is temperature, μis the viscosity of PLGA/dichloromethane (approximated as dichloromethane initially), and r A is the radius of nanoCipro.…”

Section: Dynamics Of Nanocipro Distribution In a Forming Particlementioning

confidence: 99%

NanoCipro encapsulation in monodisperse large porous PLGA microparticles

Arnold

Gorman

Schieber

et al. 2007

Journal of Controlled Release

118

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Pulmonary drug delivery of controlled release formulations may provide an effective adjunct approach to orally delivered antibiotics for clearing persistent lung infections. Dry powder formulations for this indication should possess characteristics including; effective deposition to infected lung compartments, persistence at the infection site, and steady release of antibiotic. Large porous particles (∼10-15 μm) have demonstrated effective lung deposition and enhanced lung residence as a result of their large diameter and reduced clearance by macrophages in comparison to small microparticles (∼1-5 μm). In this report, Precision Particle Fabrication technology was used to create monodisperse large porous particles of poly(D,L-lactic-co-glycolic acid) (PLGA) utilizing oils as extractable porogens. After extraction, the resulting large porous PLGA particles exhibited a low density and a web-like or hollow interior depending on porogen concentration and type, respectively. Ciprofloxacin nanoparticles (nanoCipro) created by homogenization in dichloromethane, possessed a polymorph with a decreased melting temperature. Encapsulating nanoCipro in large porous PLGA particles resulted in a steady release of ciprofloxacin that was extended for larger particle diameters and for the solid particle morphology in comparison to large porous particles. The encapsulation efficiency of nanoCipro was quite low and factors impacting the entrapment of nanoparticles during particle formation were elucidated. A dry powder formulation with the potential to control particle deposition and sustain release to the lung was developed and insight to improve nanoparticle encapsulation is discussed.

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Section: Dynamics Of Nanocipro Distribution In a Forming Particlementioning

confidence: 99%

NanoCipro encapsulation in monodisperse large porous PLGA microparticles

Arnold

Gorman

Schieber

et al. 2007

Journal of Controlled Release

118

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show abstract

“…For example, density gradient centrifugation is used in vaccine production (Aunins et al, 2000), dielectrophoresis (see Bird et al, 2002;pp. 784-785) is finding a great many applications for very small-scale separations, and magneticfields appear promising (Cramer, 2002;Zborowski et al, 2002).…”

Section: Final Purificationmentioning

confidence: 99%

“…Here a is an interphase distribution coefficient and K c,tot is an overall mass transfer coefficient to describe the combined effects of boundary-layer and intra-bead diffusional resistance (Bird et al, 2002;Sect. 22.4).…”

Section: Differential Chromatography and General Conceptsmentioning

confidence: 99%

“…(12). Note that the additivity of boundary layer and internal diffusional resistance implied by using the overall mass transfer coefficient (Bird et al, 2002;Sect. 22.4).…”

Section: Differential Chromatography and General Conceptsmentioning

confidence: 99%

“…We begin here by reviewing the basic problem of predicting water transport in ideally selective membranes, which is basically governed by boundary layer mass transport (Bird et al, 2002;p. 713).…”

Section: Ultrafiltrationmentioning

confidence: 99%

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Biotech & Bioengineering

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Here we review key applications of separation technology in applied biology. We first sketch out the field as a whole, but then narrow our scope to the processing of fermentation products, particularly to high-value biologicals such as proteins and nucleotides. We go on to provide a qualitative overview describing the importance and general nature of this large field, major trends, and the strategies that have proven most fruitful in evolving effective separation and purification processes. We then give a detailed description of individual separations equipment and the principles governing their operation. We concentrate throughout on making the available literature accessible to the reader; we provide what is hoped to be a representative set of basic references. However, these references, in turn, include some that suggest promising new developments as well as a number of more specialized reviews. We hope that our overall result provides the reader with access to the most relevant literature. B

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Application of fluid mechanic and kinetic models to characterize mammalian cell detachment in a radial-flow chamber

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DiMilla

1997

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Transport Phenomena

Cited by 982 publications

References 0 publications

NanoCipro encapsulation in monodisperse large porous PLGA microparticles

NanoCipro encapsulation in monodisperse large porous PLGA microparticles

Bioseparations

Application of fluid mechanic and kinetic models to characterize mammalian cell detachment in a radial-flow chamber

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