Transport Phenomena of Solid Particles in Pulsatile Pipe Flow

Fujimoto, Hitoshi; Kubo, Masahiro; Hama, Takayuki; Takuda, Hirohiko

doi:10.1155/2010/121326

Cited by 5 publications

(4 citation statements)

References 24 publications

(50 reference statements)

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Section: Discussionmentioning

confidence: 99%

“…Pulsitility has become increasingly utilized during delivery of suspended microspheres and has been shown in several studies to reduce the accumulation of particles under flow (Corbett, Ajdari, Coskun, & Nayeb‐Hashemi, 2010; Fujimoto, Kubo, Hama, & Takuda, 2010). This is particularly important when delivering stiffer particles with lower compliance to the microcatheter lumen during delivery, such as with DC Bead LUMI where the risk of permanent blockades could increase relative to the more compressible DC Bead, due to the radiopaque iodine component inherent within the DC Bead LUMI structure that increases hydrophobicity and decreases the overall water content of the hydrogel (Figure 7).…”

Section: Discussionmentioning

confidence: 99%

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Handling and performance characteristics of a new small caliber radiopaque embolic microsphere

et al. 2020

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The in vitro and in vivo handling and performance characteristics of a small caliber radiopaque embolic microsphere, 40–90 μm DC Bead LUMI™ (LUMI40‐90), were studied. Microsphere drug loading and elution and effects on size, suspension, and microcatheter delivery were evaluated using established in vitro methodologies. In vivo evaluations of vascular penetration (rabbit renal artery embolization), long‐term biocompatibility and X‐ray imaging properties, pharmacokinetics and local tissue effects of both doxorubicin (Dox) and irinotecan (Iri) loaded microspheres (swine hepatic artery embolization) were conducted. Compared to 70–150 μm DC Bead LUMI (LUMI70‐150), LUMI40‐90 averaged 70 μm versus 100 μm, which was unchanged upon drug loading. Handling, suspension, and microsphere delivery studies were successfully performed. Dox loading was faster (20 min) and Iri equivalent (<10 min) while drug elution rates were similar. Contrast suspension times were longer with no delivery complications. Vascular penetration was statistically greater (rabbit) with no unexpected adverse safety findings (swine). Microspheres ± drug were visible under X‐ray imaging (CT) at 90 days. Peak plasma drug levels and area under the curve were greater for LUMI40‐90 compared to LUMI70‐150 but comparable to 70–150 μm DC BeadM1™ (DC70‐150). Local tissue effects showed extensive hepatic necrosis for Dox, whereas Iri displayed lower toxicity with more pronounced lobar fibrosis. LUMI40‐90 remains suspended for longer and have greater vessel penetration compared to the other DC Bead LUMI sizes and are similarly highly biocompatible with long‐term visibility under X‐ray imaging. Drug loading is equivalent or faster with pharmacokinetics similar to DC70‐150 for both Dox and Iri.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Handling and performance characteristics of a new small caliber radiopaque embolic microsphere

et al. 2020

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“…Due to the significant difference between the density of the gas and the liquid, the particles in the gas settle much faster than the liquid. Therefore, some researchers have argued that the water phase carries the solid particle and air has no contribution in vertical transportation [5,13,14]. It should be noted that they monitored the state of small solid particles transportation in the range of bubble and slug flow.…”

Section: Particle Velocitymentioning

confidence: 99%

“…Another noteworthy point is that the particles transported by the airlift pump were small and had dimensions in the range of millimeters. Fujimoto et al [5] considered the mechanism of sphere particle transportation in pulsating water flow by stereo videography and numerical simulations. The tested particles were 3 mm and 5 mm in diameter with two densities of 3600 kg/m 3 and 2520 kg/m 3 .…”

Section: Introductionmentioning

confidence: 99%

Particle Transport Velocity in Vertical Transmission with an Airlift Pump

Enany

Shevchenko

Drebenstedt

2022

Fluids

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This paper presents the optimal conditions for fast transfer of solid particle with an airlift pump. The experimental examinations were carried out in an airlift pump with a length of 5.64 m and an inner diameter of 0.102 m in order to determine the impact of submergence ratio, air flow, and physical particle properties, such as shape, size, and density, on the vertical velocity of the particle in detail. The results showed that with the same air flow, the maximum particle velocity was achieved when the churn flow regime is established with a submergence ratio close to 0.89. However, in bubble and slug flow, it is not possible to carry a large particle in the dimensions of centimeters. Furthermore, in a churn flow, the velocity of the particle exceeds the velocity of pumped water; hence, water is not the only particle carrier in a vertical three-phase flow.

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Performance characteristics of the airlift pump under vertical solid–water–gas flow conditions for conveying centimetric-sized coal particles

Enany,

Drebenshtedt

2024

Int J Coal Sci Technol

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In this study, the installation of an airlift pump with inner diameter of 102 mm and length of 5.64 m was utilized to consider the conveying process of non-spherical coal particles with density of 1340 kg/m3 and graining 25–44.5 mm. The test results revealed that the magnitude of increase in the solid transport rate due to the changes in the three tested parameters between compressed air velocity, submergence ratio, and feeding coal possibility was not the same, which are stand in range of 20%, 75%, and 40%, respectively. Hence, creating the optimal airlift pump performance is highly dependent on submergence ratio. More importantly, we measured the solid volume fraction using the method of one-way valves in order to minimize the disadvantages of conventional devices, such as fast speed camera and conductivity ring sensor. The results confirmed that the volume fraction of the solid phase in the transfer process was always less than 12%. To validate present experimental data, the existing empirical correlations together with the theoretical equations related to the multiphase flow was used. The overall agreement between the theory and experimental solid delivery results was particularly good instead of the first stage of conveying process. This drawback can be corrected by omitting the role of friction and shear stress at low air income velocity. It was also found that the model developed by Kalenik failed to predict the performance of our airlift operation in terms of the mass flow rate of the coal particles.

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Transport Phenomena of Solid Particles in Pulsatile Pipe Flow

Cited by 5 publications

References 24 publications

Handling and performance characteristics of a new small caliber radiopaque embolic microsphere

Handling and performance characteristics of a new small caliber radiopaque embolic microsphere

Particle Transport Velocity in Vertical Transmission with an Airlift Pump

Performance characteristics of the airlift pump under vertical solid–water–gas flow conditions for conveying centimetric-sized coal particles

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