Abstract:<p>This study presents theoretical underpinnings for how the dynamic range of a lateral flow immunoassay (LFIA) may be expanded by real-time imaging. The dynamic range of a sandwich LFIA is limited by the ‘hook effect’, according to which, test line signal intensities reduce with increasing analyte concentration beyond a threshold analyte concentration. Rey et al. (<i>Anal Chem</i>, 2017, 89(9)) have shown experimentally that the hook effect in sandwich LFIAs may be mitigated by real-time ima… Show more
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