Transport of Prostaglandins through Silicone Rubber

Rosemanx, T.J.; Larion, Laura; Butler, S.S.

doi:10.1002/jps.2600700525

Cited by 9 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(19), for prostaglandin release from a polymeric matrix of silicone rubber with initial loading higher than solubility. The parameters employed were taken from Roseman et al (1981). A close match between the model and the experimental data was observed.…”

Section: Resultsmentioning

confidence: 96%

See 1 more Smart Citation

Modeling of dispersed-drug delivery from planar polymeric systems: Optimizing analytical solutions

Helbling

Ibarra

Luna

et al. 2010

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 96%

“…Fig. 9 shows experimental data reported by Roseman et al (1981) and the release profile calculated according to Eq. (19), for prostaglandin release from a polymeric matrix of silicone rubber with initial loading higher than solubility.…”

Section: Resultsmentioning

confidence: 99%

Modeling of dispersed-drug delivery from planar polymeric systems: Optimizing analytical solutions

Helbling

Ibarra

Luna

et al. 2010

International Journal of Pharmaceutics

View full text Add to dashboard Cite

“…Reliable information on the diffusion constants of cell medium components through PDMS polymer is scarce. 35,36 However, Hatanaka et al quantified the permeabilities of several common drugs through PDMS and compared this to the degree of lipophilicity (as PDMS is a highly non-polar, hydrophobic polymer) and molecular weight. 36 Diffusion rates correlated strongly with lipophilicity.…”

Section: Diffusion Of Cell Medium Components Through Pdmsmentioning

confidence: 99%

A microsystem for sensing and patterning oxidative microgradients during cell culture

et al. 2006

View full text Add to dashboard Cite

We present the design, modeling, fabrication and testing of a microsystem for the electrolytic patterning and sensing of oxidative microgradients within 1 x 1 mm2 area during cell culture. The system employs an array of microfabricated electrodes (3-40 microm in width) embedded in gas-permeable microchannels to generate precise doses of dissolved oxygen (ranging from 10 fmol O2 mm(-2) s(-1) to 100 nmol O2 mm(-2) s(-1)) via electrolysis. The microgradients generated by different microelectrodes in the array can be superimposed to pattern multi-dimensional oxygen profiles not possible with other methods. We demonstrate the patterning, sensing and quantification of dissolved oxygen microgradients in the 0 to 40% dO2 range using this microsystem. Reactive oxygen species generation and dosing is also quantified. Lastly, we demonstrate how the microtechnology enables new types of experiments in three different cell culture models: localized hyperoxia-induced apoptosis in C2C12 myoblasts, dynamic aerotaxis assays of Bacillus subtilis, and studies of calcium release in an ischemia/re-oxygenation myoblast model.

show abstract

“…One commercially available preservative free multidose eyedropper (Novelia ® , marketed by Nemera ® ) contains silicone parts isolating the solution from the outside, by using silicone's properties of gas permeation to allow pressure equilibrium with drop release and properties of shape memory to act as a valve. Silicone is a material known for being at risk of interactions with certain drugs it comes in contact with, be it wanted or not, for example proteins, ciprofloxacin and prostaglandins (4)(5)(6). Such a device is therefore especially at risk of developing interactions with the ophthalmic drugs it could be put into contact with.…”

Section: Introductionmentioning

confidence: 99%

A Sorption Study between Ophthalmic Drugs and Multi Dose Eyedroppers in Simulated Use Conditions

Basle

Chennell

Sautou

2017

Pharmaceutical Technology in Hospital Pharmacy

View full text Add to dashboard Cite

AbstractPreservative free ophthalmic formulations need to be packaged either as single doses, or using specially designed sterility preserving multidose eyedroppers. Our objective was to evaluate potential sorption phenomena between a device with a silicone sterility preserving membrane and the delivered drops of several ophthalmic solutions. Cyclosporine, rifamycin, latanoprost, timolol and norfloxacin were used as model drugs. Quantification of the active substance in delivered drops (1 to 4 drops per day) from low density polyethylene (LDPE) bottles without any sterility preserving device and from LDPE bottles with a sterility preserving silicone membrane (LDPE-Si) was performed for 14 days (n≥3), using validated HPLC methods. For cyclosporine, mean concentrations did not vary by more than 10 % from reference concentrations for either LDPE or LDPE-Si eyedroppers, but for LDPE-Si, the concentrations of the 1 mg.ml-1 cyclosporine micellar solution were found to be significantly lower than for those from LDPE eyedroppers (p=0.0127). For LDPE-Si, rifamycin mean concentrations decreased by 11.2 % throughout the 14 day study period, but didn’t vary by more than 10 % for LDPE and glass eyedroppers. However, rifamycin concentrations from LDPE-Si were not significantly different from those from LDPE eyedroppers. For latanoprost, whilst mean concentrations did not vary by more than 10 % from reference concentration for LDPE eyedroppers, for LDPE-Si eyedroppers concentrations decreased by 76.4 % at their lowest concentration and never returned to their initial level. For timolol and norfloxacin, mean concentrations did not vary by more than 10 % for either LDPE or LDPE-Si eyedroppers and no significant difference was found between the 2 eyedroppers concentrations. Our results are in favor of an absence of significant sorption between LDPE-Si eyedroppers for timolol or norfloxacin ophthalmic solutions. Further studies should be performed on cyclosporine ophthalmic micellar solutions and rifamycin ophthalmic solutions before any definite conclusions can be made. Finally, our results show that latanoprost ophthalmic solutions shouldn’t be used with LDPE-Si eyedroppers as the loss of active substance would cause a sever under-dosing.

show abstract

Transport of Prostaglandins through Silicone Rubber

Cited by 9 publications

References 21 publications

Modeling of dispersed-drug delivery from planar polymeric systems: Optimizing analytical solutions

Modeling of dispersed-drug delivery from planar polymeric systems: Optimizing analytical solutions

A microsystem for sensing and patterning oxidative microgradients during cell culture

A Sorption Study between Ophthalmic Drugs and Multi Dose Eyedroppers in Simulated Use Conditions

Contact Info

Product

Resources

About