-I n assessing the hazard o f exposure t o airborne plutonium, questions a r i s e as t o the r e l a t i v e importance o f material deposited w i t h i n the r e s p i r a t o r y t r a c t and on skin. To provide relevant deposition data, shaved r a t s were exposed t o a 2 3 8~u (~0 3 ) 4 aerosol i n a low-speed windtunnel.H a l f were oriented w i t h noses facing upstream, the other h a l f w i t h noses downstream. Samples o f the airstream were taken during exposure t o determine the aerosol concentration and i t s aerodynamic equivalent s i z e d i s t r i b u t i o n . Calculations o f the quantity inhaled were made fro111 the aerosol concentration, minute volume and exposure time; skin deposition was estimated from the aerosol deposition velocity, area o f exposed s k i n and exposure time. Imnediately a f t e r exposure, the r a t s were sacrificed, skinned and dissected and the p l utoni um a c t i v i t y on the s k i n compared t o t h a t i n lungs, head and i n t e s t i n e s .
Rats w i t h t h e i r noses downstream inhaled only
DISCLAIMERPortions of this document may be illegible in electronic image products. Images are produced from the best available original document.t h e upstream group. I n b o t h cases, about 40% of t h e i n h a l e d m a t e r i a l was i n t h e lower r e s p i r a t o r y t r a c t , about 40% i n the head and 20% i n t h e i n t e s t i n e s . Plutonium deposited on the s k i n s o f t h e two groups was almost i d e n t i c a l , b e i n g 22 t o 33% o f t h e r e s p i r a t o r y t r a c t value. Measured values agreed w i t h t h e c a l c u l a t e d values w i t h i n a f a c t o r o f two.