Transport of histamine by vesicular monoamine transporter-2

Corticosterone-Sensitive Monoamine Transport in the Rat Dorsomedial Hypothalamus: Potential Role for Organic Cation Transporter 3 in Stress-Induced Modulation of Monoaminergic Neurotransmission

“…For this reason, we used two additional measures to more specifically characterize OCT-mediated transport in acutely dissected brain tissues. First, uptake of [ 3 H]-histamine by 3V-MH minces: of the above-mentioned transporters, only OCT2, OCT3, and VMAT2 are known to transport histamine (Merickel and Edwards, 1995;Dimaline and Struthers, 1996;Grundemann et al, 1999). Second, efflux of [ 3 H]-MPP ϩ from preloaded hypothalamic minces: although SERT, DAT, and NET are capable of transporting MPP ϩ , they are all predominantly unidirectional uptake transporters under physiological conditions (Levi and Raiteri, 1993;Scholze et al, 2002;Reed et al, 2003), whereas the OCTs are truly bidirectional transporters (Jonker and Schinkel, 2004).…”

Histamine (re)uptake by astrocytes: an experimental and computational study

“…In the brain histamine is synthesized from histidine by a specific enzyme L-histidine decarboxylase (HD) [3] and is taken up into synaptic vesicles by the vesicular monoamine transporter 2 (VMAT2) [4]. It is released into synaptic cleft upon depolarization, which is followed by its removal from synaptic cleft in a relatively short time.…”

Redefinition of the human mast cell transcriptome by deep-CAGE sequencing

“…Although several genes are associated with MC biology (such as granule biosynthesis/function 33,34 ), the function of others is currently ignored. This indicates that our view of MCs is largely incomplete.…”