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Postmortem findings of pipamperone after fatal intoxications and its distribution in body fluids and tissues

“…Furthermore, Bont et al reported a non‐fatal pipamperone intoxication in which the determined serum concentration of 3.2 μg/mL was highly above the known toxic concentration range of 0.5–0.6 μg/mL . Another non‐fatal intoxication was caused by the intake of 2000 mg pipamperone . In summary, toxic concentrations of pipamperone can lead to a non‐fatal intoxication and fatal intoxications related to pipamperone have been based on drug–drug interactions up to now.…”

“…However, an overdose can result, inter alia, in seizures (1600 mg pipamperone) and coma (1200 mg pipamperone) . Its toxic effect “consists of benign tachycardia, hypotension and electrocardiographic changes among which are Q‐T interval prolongation and T wave changes” which can lead to torsade de pointes …”

“…3 Its toxic effect "consists of benign tachycardia, hypotension and electrocardiographic changes among which are Q-T interval prolongation and T wave changes" which can lead to torsade de pointes. [5][6][7] Non-fatal as well as fatal intoxications, which are related to therapeutic up to toxic concentrations of pipamperone, may be triggered by drug-drug interactions. [8][9][10][11] Furthermore, Bont et al reported a non-fatal pipamperone intoxication in which the determined serum concentration of 3.2 μg/mL was highly above the known toxic concentration range of 0.5-0.6 μg/mL.…”

“…6,12 Another non-fatal intoxication was caused by the intake of 2000 mg pipamperone. 7 In summary, toxic concentrations of pipamperone can lead to a non-fatal intoxication and fatal intoxications related to pipamperone have been based on drug-drug interactions up to now.…”