Transport in QSAR V

Modeling Kinetics of Subcellular Disposition of Chemicals

“…He extended the results for the initial distribution period to multiple bilayer systems and showed that the concentrations are proportional to the product of the transfer rate parameters of involved steps. 2084,2085 …”

“…He extended the results for the initial distribution period to multiple bilayer systems and showed that the concentrations are proportional to the product of the transfer rate parameters of involved steps. 2084,2085 Some attempts 67,2086 at description of the concentrationlipophilicity profiles were based on the use of a reduced time τ (where τ ) l o t, with l o being the transfer rate parameter for the membrane-water direction and t being time; see Figure 7 in section 2.1.4.6). The reduced time τ is proportional to the real time t only when l o is a constant, which holds for P , 1/B t , as follows from eqs 3 in section 2.1.3.4.…”

Membrane Transport and Cellular Distribution

“…Here, k is the rate constant of diffusion in the diffusion layer indicated by the subscript that can be expressed using the diffusion coefficient D and the effective thickness h of the corresponding diffusion layer as k = D/h [9]. A steady-state description of the process [6-81 shows that the empirical parameters in Eq.…”

“…pH, = @He + Vl (9) where the sensitivity 6 is assumed to be constant for all the intracellular phases. Then all the terms A, B, C, D in Eq.…”

Transport in Quantitative Structure-activity Relationships VI: Relationship Between Transport Rate Constants and Partition Coefficients

“…Moreover, it can be understood from this theory how drug transport in a biological system can be described with partition coefficients and why bilinear and parabolic relationships are found experimentally (6). This new interfacial drug transfer model is related closely to other literature models (6).…”