Transport du Na<sup>+</sup>dans les poumons

Dagenais, André; Boncoeur, Émilie; Berthiaume, Yves

doi:10.1051/medsci/20092510815

Med Sci (Paris)

2009

DOI: 10.1051/medsci/20092510815

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Transport du Na⁺dans les poumons

André Dagenais

Émilie Boncoeur

Yves Berthiaume

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Cited by 3 publications

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“…Active Na+ transport is the main driving force of the physiological process leading to edema clearance from the alveolar space. The epithelial sodium channel (ENaC) at the apical surface and the sodium-potassium adenosine triphosphatase (Na+-K+-ATPase) at the basolateral surface of alveolar epithelial cells are two essential components of this alveolar liquid clearance, as they create an osmotic gradient that leads to transalveolar liquid transport [4][5][6]. Several compounds have been shown to stimulate this sodium-dependent alveolar liquid clearance mechanism [7][8][9].…”

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confidence: 99%

Effect of adrenalectomy on pulmonary edema resolution

Massé

Berthiaume

2019

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Purpose: The capacity of the lung to clear edema fluid has been shown to be one of the factors that can influence the prognosis of cardiogenic and noncardiogenic pulmonary edema. Active Na+ transport across the alveolar epithelium is the main driving force involved in this physiological process. Since endogenous catecholamines are known to activate the sodium-dependent mechanism of alveolar edema clearance, the objective of the present study was to explore if adrenalectomy, which prevents the release of endogenous catecholamines and other hormones, such as corticosterone, into circulation, would affect edema resolution in a model of lung injury induced by thiourea. Methods: A high-permeability pulmonary edema was induced in adult male Sprague-Dawley rats using a thiourea-induced pulmonary edema model. To determine if the release of adrenalin and corticosterone is essential for resolution of the thiourea-induced edema, we measured 1) the release of adrenalin and corticosterone in urine and 2) edema resolution in control animals and adrenalectomized animals. Results: The administration of thiourea significantly increased the wet-to-dry ratio after four and eight hours. After 12 and 24 hours, the wet-to-dry ratio gradually returned to baseline. Although thiourea-induced pulmonary edema was associated with a significant increase in urine adrenalin and corticosterone, the absence of adrenalin and corticosterone response in adrenalectomized animals did not prevent the resolution of the edema. Conclusions: These experiments demonstrated that resolution of thioureainduced pulmonary edema can occur in the absence of hormonal secretion by the adrenal glands.

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Effect of adrenalectomy on pulmonary edema resolution

Massé

Berthiaume

2019

CIM

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Fine-mapping the MHC region in Asian populations identified novel variants modifying susceptibility to lung cancer

et al. 2017

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Alveolar liquid clearance in lung injury: Evaluation of the impairment of the β2-adrenergic agonist response in an ischemia-reperfusion lung injury model

Richard

Shabbir

Ferraro

et al. 2019

Respiratory Physiology & Neurobiology

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Transport du Na⁺dans les poumons

Cited by 3 publications

References 34 publications

Effect of adrenalectomy on pulmonary edema resolution

Effect of adrenalectomy on pulmonary edema resolution

Fine-mapping the MHC region in Asian populations identified novel variants modifying susceptibility to lung cancer

Alveolar liquid clearance in lung injury: Evaluation of the impairment of the β2-adrenergic agonist response in an ischemia-reperfusion lung injury model

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Transport du Na+dans les poumons

Cited by 3 publications

References 34 publications

Effect of adrenalectomy on pulmonary edema resolution

Effect of adrenalectomy on pulmonary edema resolution

Fine-mapping the MHC region in Asian populations identified novel variants modifying susceptibility to lung cancer

Alveolar liquid clearance in lung injury: Evaluation of the impairment of the β2-adrenergic agonist response in an ischemia-reperfusion lung injury model

Contact Info

Product

Resources

About

Transport du Na⁺dans les poumons