Transport-dependent maturation of organelles in neurons

Mathew, Amal; Koushika, Sandhya P.

doi:10.1016/j.ceb.2022.102121

Current Opinion in Cell Biology

2022

DOI: 10.1016/j.ceb.2022.102121

|View full text |Cite

Transport-dependent maturation of organelles in neurons

Amal Mathew

Sandhya P. Koushika

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Driven by motor proteins running along microtubule networks, axonal transport is essential for neuronal survival, as evidenced by perturbations observed in disease models, as well as mutations in transport machinery causing neurodegeneration. 1 Axonal transport is finely controlled 2 , is closely linked with organelle maturation 3 , and has been shown to be coupled with mRNA tethering to facilitate local protein translation. 4 This summary highlights recent advances supporting the emergence of alterations in the axonal cytoskeleton and trafficking as drivers of neurological diseases.…”

mentioning

confidence: 99%

Neuroscience highlights in 2022: cytoskeletal transport

Sleigh¹,

Schiavo²

2023

The Lancet Neurology

View full text Add to dashboard Cite

mentioning

confidence: 99%

Neuroscience highlights in 2022: cytoskeletal transport

Sleigh¹,

Schiavo²

2023

The Lancet Neurology

View full text Add to dashboard Cite

A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo

Lesport,

Commeau,

Genet

et al. 2024

Front. Cell. Neurosci.

View full text Add to dashboard Cite

The failure of the autophagy-lysosomal pathway to clear the pathogenic forms of Tau exacerbates the pathogenesis of tauopathies. We have previously shown that the immunophilin FKBP52 interacts both physically and functionally with Tau, and that a decrease in FKBP52 protein levels is associated with Tau deposition in affected human brains. We have also shown that FKBP52 is physiologically present within the lysosomal system in healthy human neurons and that a decrease in FKBP52 expression alters perinuclear lysosomal positioning and Tau clearance during Tau-induced proteotoxic stress in vitro. In this study, we generate a zebrafish fkbp4 loss of function mutant and show that axonal retrograde trafficking of Lamp1 vesicles is altered in this mutant. Moreover, using our transgenic HuC::mCherry-EGFP-LC3 line, we demonstrate that the autophagic flux is impaired in fkbp4 mutant embryos, suggesting a role for Fkbp52 in the maturation of autophagic vesicles. Alterations in both axonal transport and autophagic flux are more evident in heterozygous rather than homozygous fkbp4 mutants. Finally, taking advantage of the previously described A152T-Tau transgenic fish, we show that the clearance of pathogenic A152T-Tau mutant proteins is slower in fkbp4+/− mutants in comparison to fkbp4+/+ larvae. Altogether, these results indicate that Fkbp52 is required for the normal trafficking and maturation of lysosomes and autophagic vacuoles along axons, and that its decrease is sufficient to hinder the clearance of pathogenic Tau in vivo.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Transport-dependent maturation of organelles in neurons

Cited by 2 publications

References 86 publications

Neuroscience highlights in 2022: cytoskeletal transport

Neuroscience highlights in 2022: cytoskeletal transport

A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo

Contact Info

Product

Resources

About