Transport-associated pathway responses in ovine fetal membranes to changes in amniotic fluid dynamics

Cheung, Cecilia Y.; Anderson, Debra F.; Brace, Robert A.

doi:10.14814/phy2.13455

Cited by 7 publications

(8 citation statements)

References 43 publications

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“…Even though basal IMARs of 700 -1,000 ml/day were unexpectedly high in the improved fetal sheep model when IMAR was directly determined (9,22,24,(31)(32)(33)83), infusion of lactated Ringer solution into the AF greatly increased IMAR (24, 83), consistent with several earlier studies showing increased IMAR in response to either intra-amniotic fluid infusions or fetal polyuria induced by intravascular fluid infusions (13,35,(42)(43)(44). We had long suspected that the increased IMARs during fetal infusions were due to either dilution of a substance in the AF that was inhibiting IMA absorption or entry into the AF of a stimulator of IMA in response to the infusions.…”

Section: Discovery Of Stimulatory and Inhibitory Factors For Intramembranous Absorptionmentioning

confidence: 98%

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Regulation of amniotic fluid volume: insights derived from amniotic fluid volume function curves

Brace

Cheung

Anderson

2018

American Journal of Physiology-Regulatory, Integrative and Comp

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Recent advances in understanding the regulation of amniotic fluid volume (AFV) include that AFV is determined primarily by the rate of intramembranous absorption (IMA) of amniotic fluid across the amnion and into fetal blood. In turn, IMA rate is dependent on the concentrations of yet-to-be identified stimulator(s) and inhibitor(s) that are present in amniotic fluid. To put these concepts in perspective, this review 1) discusses the evolution of discoveries that form the current basis for understanding the regulation of AFV, 2) reviews the contribution of IMA to this regulation, and 3) interprets experimentally induced shifts in AFV function curves and amnioinfusion function curves in terms of the activity of the amniotic fluid stimulator and inhibitor of IMA. In the early 1980s, it was not known whether AFV was regulated. However, by the late 1980s, IMA was discovered to be a "missing link" in understanding the regulation of AFV. Over the next 25 years the concept of IMA evolved from being a passive process to being an active, unidirectional transport of amniotic fluid water and solutes by vesicles within the amnion. In the 2010s, it was demonstrated that a renally derived stimulator and a fetal membrane-derived inhibitor are present in amniotic fluid that regulate IMA rate and hence are the primary determinants of AFV. Furthermore, AFV function curves and amnioinfusion function curves provide new insights into the relative efficacy of the stimulator and inhibitor of IMA.

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Section: Discovery Of Stimulatory and Inhibitory Factors For Intramembranous Absorptionmentioning

confidence: 98%

“…This led to our speculation that VEGF may play a primary role in regulating IMAR (28). However, recent studies found that amnion VEGF mRNA levels are also elevated when IMAR is experimentally reduced (33), suggesting that VEGF may not be a major regulator of IMAR.…”

Section: Induced Molecular Changes Within Amnionmentioning

confidence: 99%

Regulation of amniotic fluid volume: insights derived from amniotic fluid volume function curves

Brace

Cheung

Anderson

2018

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Three families of VEGF proteins and their corresponding receptors have been characterized and the main receptors involved in the first steps of signal transduction cascades comprise different tyrosine kinases receptors, such as VEGFR-1, VEGFR-2, and VEGFR-3 [ 42 ]. Across species, some VEGF family members and receptors are found in placentomes, uterus tissues, and oviduct, and in different species including humans, mice, rats, cattle, sheep, pigs, and rabbits [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. The in vivo administration of VEGF to goats and sheep stimulates follicular growth and increases the number of preovulatory follicles [ 51 ].…”

Section: Growth Factors and Early Developmentmentioning

confidence: 99%

Pluripotency and Growth Factors in Early Embryonic Development of Mammals: A Comparative Approach

Llobat

2021

Veterinary Sciences

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The regulation of early events in mammalian embryonic development is a complex process. In the early stages, pluripotency, cellular differentiation, and growth should occur at specific times and these events are regulated by different genes that are expressed at specific times and locations. The genes related to pluripotency and cellular differentiation, and growth factors that determine successful embryonic development are different (or differentially expressed) among mammalian species. Some genes are fundamental for controlling pluripotency in some species but less fundamental in others, for example, Oct4 is particularly relevant in bovine early embryonic development, whereas Oct4 inhibition does not affect ovine early embryonic development. In addition, some mechanisms that regulate cellular differentiation do not seem to be clear or evolutionarily conserved. After cellular differentiation, growth factors are relevant in early development, and their effects also differ among species, for example, insulin-like growth factor improves the blastocyst development rate in some species but does not have the same effect in mice. Some growth factors influence genes related to pluripotency, and therefore, their role in early embryo development is not limited to cell growth but could also involve the earliest stages of development. In this review, we summarize the differences among mammalian species regarding the regulation of pluripotency, cellular differentiation, and growth factors in the early stages of embryonic development.

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“…In animal studies, the effect of fetal urinary prostaglandin E 2 on IM transport was explored but results did not support such a role (Cheung, Beardall, Anderson, & Brace, 2014). Conversely, AQP1 appeared to play a positive role in regulating the rate of IM transport (Cheung, Anderson, & Brace, 2016) while the growth and permeability factor vascular endothelial growth factor (VEGF) may mediate amniotic fluid transport across the amnion (Cheung, Anderson, & Brace, 2017). Recently, we reported that IM transport across the amnion is a multifactorial regulatory process that involves cellular transport pathways and signaling modulators.…”

Section: Introductionmentioning

confidence: 99%

Altered proteomics profile in the amnion of patients with oligohydramnios

Cheung

Brace

2020

Physiol Rep

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In pregnancy, idiopathic oligohydramnios is an obstetrical complication that compromises maternal health with poor perinatal outcome. Effective therapeutic treatment of this condition has been hampered by the unknown etiology and lack of understanding of cellular and molecular mechanisms that underlie idiopathic oligohydramnios. Amniotic fluid volume (AFV) is determined by intramembranous (IM) transport of amniotic fluid across the amnion and this pathway is regulated to maintain AFV within the normal range. To gain understanding of the causes of idiopathic oligohydramnios, we performed proteomics analysis of the human amnion to investigate the changes in protein expression profiles of cellular transport pathways and regulators in patients with oligohydramnios. Placental amnions from five patients with normal pregnancies and five patients with oligohydramnios were subjected to proteomics experiments followed by bioinformatics analysis. Using Ingenuity Pathway Analysis (IPA) software, five categories of biological functions and multiple canonical pathways within each category were revealed. The top differentially expressed proteins that participate in mediating these pathways were identified. The functional pathways activated include: (a) cellular assembly and organization, (b) cell signaling and energy metabolism, and (c) immunological, infectious, and inflammatory functions. Furthermore, the analysis identified the category of pathways that facilitate molecular endocytosis and vesicular uptake. Under oligohydramniotic conditions, the mediators of clathrin vesicle‐mediated uptake and transport as well as intracellular trafficking mediators were up‐regulated. These findings suggest that idiopathic oligohydramnios may be associated with alternations in cellular organization and immunological functions as well as increases in activity of vesicular transport pathways across the amnion.

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Transport-associated pathway responses in ovine fetal membranes to changes in amniotic fluid dynamics

Cited by 7 publications

References 43 publications

Regulation of amniotic fluid volume: insights derived from amniotic fluid volume function curves

Regulation of amniotic fluid volume: insights derived from amniotic fluid volume function curves

Pluripotency and Growth Factors in Early Embryonic Development of Mammals: A Comparative Approach

Altered proteomics profile in the amnion of patients with oligohydramnios

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