2012
DOI: 10.1016/j.bbrc.2012.06.007
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Transport activities and expression patterns of glycine transporters 1 and 2 in the developing murine brain stem and spinal cord

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Cited by 7 publications
(6 citation statements)
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“…On the other hand, GlyT2 displays weak expression in the brain cortex and hippocampus, but is more abundant in the cerebellum (Jursky et al, 1994; Jursky and Nelson, 1996). Remarkably, the progressive development observed in the spinal cord where GlyT2 increases in expression to regulate the level of glycine in combination with GlyT1 (Lall et al, 2012) does not seem to occur in the developing brain. In contrast, later during postnatal development glycine level is exclusively controlled by GlyT1 independently of GlyT2 in the cortex (Gomeza et al, 2003; Kunz et al, 2012).…”
Section: Glycine Receptors Endogenous Agonists During Developmentmentioning
confidence: 99%
“…On the other hand, GlyT2 displays weak expression in the brain cortex and hippocampus, but is more abundant in the cerebellum (Jursky et al, 1994; Jursky and Nelson, 1996). Remarkably, the progressive development observed in the spinal cord where GlyT2 increases in expression to regulate the level of glycine in combination with GlyT1 (Lall et al, 2012) does not seem to occur in the developing brain. In contrast, later during postnatal development glycine level is exclusively controlled by GlyT1 independently of GlyT2 in the cortex (Gomeza et al, 2003; Kunz et al, 2012).…”
Section: Glycine Receptors Endogenous Agonists During Developmentmentioning
confidence: 99%
“…Manipulation of the excitatory-inhibitory input balance alters the onset and closure of the critical period in the developing visual cortex 21 . Inhibitory neural activity increases with development in the spinal cord 22 23 24 . Glycinergic inhibition predominates over GABAergic inhibition in the ventral spinal cord 27 , where the density of glycine receptors increases during development 22 23 .…”
Section: Resultsmentioning
confidence: 99%
“…Inhibitory neural activity increases with development in the spinal cord 22 23 24 . Glycinergic inhibition predominates over GABAergic inhibition in the ventral spinal cord 27 , where the density of glycine receptors increases during development 22 23 . To test whether termination of the critical period can be affected by development of inhibitory neural activity in the spinal cord, we partially blocked glycinergic receptors by adding a low dose (0.2 μM) of strychnine to co-cultures for a period that extended beyond the end of the critical period (9–15 DIV) 28 29 .…”
Section: Resultsmentioning
confidence: 99%
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“…However, several reports provide evidence that this is not the case. Lall et al (2012) have reported that the expression levels of both GlyT1 and GlyA differ by 20% in the brain stems of 10-day-old mouse Fig. 6.…”
Section: Discussionmentioning
confidence: 98%