Transplanted neural-like cells improve memory and Alzheimer-like pathology in a rat model

Hoveizi, Elham; Mohammadi, Tayebeh; Moazedi, Ahmad Ali; Zamani, Nastaran; Eskandary, Azade

doi:10.1016/j.jcyt.2018.03.036

Cited by 14 publications

(9 citation statements)

References 30 publications

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“…Transplantation of ESC-derived neural progenitor cells (NPCs) into AD animal models can result in a therapeutic outcome, through differentiation into astrocytic and neuron-like cells and enhancing memory performance (Tang et al 2008). In addition, transplanting "neuron-like cell (NLC)-derived mouse ESCs (mESCs)" into AD-induced rats enhanced the neuronal connectivity and reduced brain lesions (Hoveizi et al 2018).…”

Section: Embryonic Stem Cells (Escs)mentioning

confidence: 99%

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Fouad

2019

Bull Natl Res Cent

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Alzheimer's disease (AD) is a neurodegenerative disorder that impairs memory formation and disrupts neurocognitive function. This neuropathy is characterized by neural loss, neurodegeneration, and formation of amyloid plaques and neurofibrillary tangles. Approved medications provide only symptomatic relief without affecting AD progression. Because of the multifactorial nature of AD and the absence of effective treatment, stem cell-based therapy has been regarded as an effective, safe, and innovative therapeutic approach to overcome AD. Different sources of stem cells are employed for AD treatment, such as neural stem cells (NSCs), mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). There is a growing body of evidence supporting the promising therapeutic potential of stem cell transplantation, which might be attributed to the mechanistic actions exerted by stem cells such as inducing hippocampal neurogenesis, secreting paracrine factors, exerting anti-inflammatory activity, showing anti-amyloidogenic potential, and finally resulting in cognitive recovery. Although stem cell-based therapy faces potential hurdles, it holds a potential hope to provide a safe, effective, and feasible clinical application of stem cells in AD patients.

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Section: Embryonic Stem Cells (Escs)mentioning

confidence: 99%

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Fouad

2019

Bull Natl Res Cent

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“…For example, NSCs derived from neonatal rats’ hippocampus were implanted into the brain of AD rats and were able to differentiate into the new cholinergic neurons and improved the ability of spatial learning and memory for AD rodent models [86]. Also, neuron-like cell (NLC)-derived mouse embryonic stem cells (mESCs) that were injected into AD rats resulted in the repair of brain lesions [87].…”

Section: Stem Cells Against Neurodegenerative Disordersmentioning

confidence: 99%

Recent advances in stem cells therapy: A focus on cancer, Parkinson’s and Alzheimer’s

Fleifel

Rahmoon

AlOkda

et al. 2018

Journal of Genetic Engineering and Biotechnology

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Stem cells serve as potential therapeutics due to their high proliferative capacity, low immunogenic reactivity and their differentiating capabilities. Several pre-clinical and early-stage clinical studies are carried out to treat genetic diseases, cancers and neurodegenerative disorders with promising preliminary results. However, there are still many challenges that scientists are trying to overcome such as the unclear expression profile of stem cells in vivo, the homing of stem cells to the site of injury and their potential immune-reactivity. Prospective research lies in gene editing of autologous stem cells in vitro and safe injection of these modified cells back into patients. Here, we review the clinical trials executed using stem cell therapy in an attempt to cure challenging diseases like cancer, Parkinson’s and Alzheimer’s diseases.

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“…The sources of stem cells may be autologous, allogenic, or iPS-derived. Generally, allogenic stem cells are prepared from placenta, umbilical cord, and embryonic tissue [ 14 – 16 ]. Autologous stem cells are isolated from brain, fat, or bone marrow [ 17 – 19 ].…”

Section: An Overview Of Stem Cell Therapy For Alzheimer’s Diseasementioning

confidence: 99%

The functional mechanism of bone marrow-derived mesenchymal stem cells in the treatment of animal models with Alzheimer’s disease: crosstalk between autophagy and apoptosis

Qin

Bai

et al. 2022

Stem Cell Res Ther

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The transplantation of bone marrow-derived mesenchymal stem cells (BMMSCs) alleviates neuropathology and improves cognitive deficits in animal models with Alzheimer’s disease. However, the underlying mechanism remains undefined. Based on meta-analysis and comprehensive review, high-profile studies support the theory that transplanted BMMSCs activate autophagy, as evidenced by the expression levels of signal molecules such as Beclin-1, Atg5, LC3-II, and mTOR. Functional autophagy mitigates neuronal apoptosis, which is reflected by the alterations of IAPs, Bcl-2, caspase-3, and so forth. Moreover, the transplantation of BMMSCs can decrease aberrant amyloid-beta peptides as well as tau aggregates, inhibit neuroinflammation, and stimulate synaptogenesis. There is a signal crosstalk between autophagy and apoptosis, which may be regulated to produce synergistic effect on the preconditioning of stem cells. Forasmuch, the therapeutic effect of transplanted BMMSCs can be enhanced by autophagy and/or apoptosis modulators.

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Transplanted neural-like cells improve memory and Alzheimer-like pathology in a rat model

Cited by 14 publications

References 30 publications

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Stem cells as a promising therapeutic approach for Alzheimer’s disease: a review

Recent advances in stem cells therapy: A focus on cancer, Parkinson’s and Alzheimer’s

The functional mechanism of bone marrow-derived mesenchymal stem cells in the treatment of animal models with Alzheimer’s disease: crosstalk between autophagy and apoptosis

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