Transplantation Resistance to a Rous Sarcoma Virus-Induced Tumor in Mice Immunized With v-src Protein1

Kuzumaki, Noboru; Fujita, Hisakazu; Dosaka, Hirotoshi; Katabami, Motoo; Levinson, Arthur D.

doi:10.1093/jnci/80.12.959

Cited by 3 publications

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“…Preinfection with src mutants that encode normal N termini and induce slow-growing tumors failed to elicit a protective effect. On the contrary, the v-src gene product has been shown to induce transplantation resistance to RSV-transformed mouse cells not producing infectious virus (Kuzumaki et al 1988;Suda et al 1988). Whether such resistance can be detected in chickens carrying a favorable haplotype will be tested, using transplantable syngeneic LTR, v-src, LTR tumor lines for challenge.…”

Section: Discussionmentioning

confidence: 99%

Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens

et al. 1992

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We report that the cloned DNA harboring the long terminal repeat (LTR), v-src, LTR proviral structure is tumorigenic in chickens of the Prague congenic lines. The growth rate of these tumors is by far the highest in the recombinant CC.R1 line, the B haplotype of which is composed of the B-F/L4 and B-G12 subregions originating from different naturally occurring haplotypes. Some of the tumors induced by the LTR, v-src, LTR DNA are repeatedly transplantable in syngeneic chickens, maintain unaltered provirus, and express v-src mRNA. Differences in the response to challenge with Rous sarcoma virus (RSV) and LTR, v-src, LTR DNA on a given experimental model are compared and possible involvement of an interaction between B-F/L and B-G region genes is considered. Regression of the LTR, v-src, LTR DNA-induced tumors did not prevent the formation and growth of tumors induced subsequently by RSV.

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Section: Discussionmentioning

confidence: 99%

Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens

et al. 1992

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src-specific immunity in inbred chickens bearing v-src DNA- and RSV-induced tumors

et al. 1994

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The growth pattern (progression/regression) of v-src DNA- and Rous sarcoma virus (RSV)-induced tumors was analogous on a panel of inbred chicken lines. The decisive role of the major histocompatibility complex [Mhc(B)] alleles in resistance to the progression of these tumors was formally proved in segregating backcross populations. The immune mechanism of tumor regression was demonstrated by both in vivo and in vitro assays. A protective effect of v-src-specific immunity against RSV challenge was shown in Rous sarcoma regressor, line CB (B12/B12). Immune cells from regressors of v-src DNA-induced tumors can protect syngeneic hosts from the development of tumor after challenge with both v-src DNA and RSV. Suppression of RSV-induced tumor cell growth in vitro was also achieved by the use of cocultivation with spleen cells from chickens in which v-src DNA-induced tumors had regressed. This in vitro sarcoma-specific response was Mhc(B)-restricted. Chickens of the congenic Rous sarcoma progressor line CC (B4/B4) are sometimes able to regress v-src DNA-induced tumors, but immune cells can only slow the growth of v-src DNA-induced tumors in syngeneic hosts. This suggests that the primary reason for the susceptibility of CC chickens is a weak v-src-specific immune response. Furthermore, some of the v-src DNA-induced tumors were transplantable across the Mhc(B) barrier. The growth of tumor allografts was able to be facilitated when immunological tolerance to the B-F/L region antigens (class I and class II) had been established. This demonstrated that a high tumorigenicity of the transplantable tumor was not due to the lack of Mhc(B) antigens on tumor cells.

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Endogenous c-src as a determinant of the tumorigenicity of src oncogenes.

Halpern¹,

England²,

Kopen³

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

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Transplantation Resistance to a Rous Sarcoma Virus-Induced Tumor in Mice Immunized With v-src Protein1

Cited by 3 publications

References 0 publications

Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens

Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens

src-specific immunity in inbred chickens bearing v-src DNA- and RSV-induced tumors

Endogenous c-src as a determinant of the tumorigenicity of src oncogenes.

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