Transplantation Referral Patterns for Patients with Newly Diagnosed Higher-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia at Academic and Community Sites in the Connect® Myeloid Disease Registry: Potential Barriers to Care

Tomlinson, Benjamin; Lima, Marcos de; Cogle, Christopher R.; Thompson, Michael A.; Grinblatt, David L.; Pollyea, Daniel A.; Komrokji, Rami S.; Roboz, Gail J.; Savona, Michael R.; Sekeres, Mikkael A.; Abedi, Mehrdad; Kurtin, Sandra; Maciejewski, Jaroslaw P.; Patel, Jay L.; Revicki, Dennis A.; George, Tracy I.; Flick, E. Dawn; Kiselev, Pavel; Louis, Chrystal U.; DeGutis, Irene S.; Nifenecker, Melissa; Erba, Harry P.; Steensma, David P.; Scott, Bart L.

doi:10.1016/j.jtct.2023.04.011

Transplantation and Cellular Therapy

2023

DOI: 10.1016/j.jtct.2023.04.011

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Transplantation Referral Patterns for Patients with Newly Diagnosed Higher-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia at Academic and Community Sites in the Connect® Myeloid Disease Registry: Potential Barriers to Care

Benjamin Tomlinson¹,

Marcos de Lima²,

Christopher R. Cogle³

et al.

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2024

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Cited by 2 publications

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Applying Implementation Science in the Field of Transplant and Cellular Therapy

DeSalvo,

Spellman,

Coles

et al. 2024

Transplantation and Cellular Therapy

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Applying Implementation Science in the Field of Transplant and Cellular Therapy

DeSalvo,

Spellman,

Coles

et al. 2024

Transplantation and Cellular Therapy

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Management of adult patients with CMML undergoing allo-HCT: recommendations from the EBMT PH&G Committee

Onida,

Gagelmann,

Chalandon

et al. 2024

Blood

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Chronic myelomonocytic leukemia (CMML) is a heterogeneous disease presenting with either myeloproliferative or myelodysplastic features. Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only potentially curative option, but the inherent toxicity of this procedure makes the decision to proceed to allo-HCT challenging, particularly as patients with CMML are mostly older and comorbid. Therefore, the decision between a non-intensive treatment approach and allo-HCT represents a delicate balance, especially since prospective randomized studies are lacking and retrospective data in the literature is conflicting. International consensus on the selection of patients and the ideal timing of allo-HCT specifically in CMML could not be reached in international recommendations published six years ago. Since then, new, CMML-specific data have been published. The European Society for Blood and Marrow Transplantation (EBMT) Practice Harmonization and Guidelines Committee assembled a panel of experts in the field to provide the first best practice recommendations on the role of allo-HCT specifically in CMML. Recommendations were based on the results of an international survey, a comprehensive review of the literature, and expert opinions on the subject, after structured discussion and circulation of recommendations. Algorithms for patient selection, timing of allo-HCT during the course of the disease, pre-transplant strategies, allo-HCT modality, as well as post-transplant management for patients with CMML were outlined.

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Transplantation Referral Patterns for Patients with Newly Diagnosed Higher-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia at Academic and Community Sites in the Connect® Myeloid Disease Registry: Potential Barriers to Care

Cited by 2 publications

References 42 publications

Applying Implementation Science in the Field of Transplant and Cellular Therapy

Applying Implementation Science in the Field of Transplant and Cellular Therapy

Management of adult patients with CMML undergoing allo-HCT: recommendations from the EBMT PH&G Committee

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