Transplantation of Schwann cells to subarachnoid space induces repair in contused rat spinal cord

Firouzi, Masoumeh; Moshayedi, Pouria; Saberi, Hooshang; Mobasheri, Hamid; Abolhassani, Farid; Jahanzad, Issa; Raza, Mohsin

doi:10.1016/j.neulet.2006.03.070

Cited by 45 publications

(24 citation statements)

References 19 publications

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“…It should be pointed out that in one of these two positive studies, efficacy was not observed with wildtype SCs, but rather in SCs transduced to express the cell adhesion molecule PSA. In the other positive study, an astonishing BBB improvement from 9 to 13.5 was reported using the mere injection of 50,000 neonatal SCs into the subarachnoid space after clip compression injury (Firouzi et al, 2006). It should be noted that the rats in this study were very young (100-140 grams), which corresponds with 45-60 days of age.…”

Section: Behaviormentioning

confidence: 50%

A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury

Tetzlaff

Okon

Karimi-Abdolrezaee

et al. 2011

Journal of Neurotrauma

480

454

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Cell transplantation therapies have become a major focus in pre-clinical research as a promising strategy for the treatment of spinal cord injury (SCI). In this article, we systematically review the available pre-clinical literature on the most commonly used cell types in order to assess the body of evidence that may support their translation to human SCI patients. These cell types include Schwann cells, olfactory ensheathing glial cells, embryonic and adult neural stem=progenitor cells, fate-restricted neural=glial precursor cells, and bone-marrow stromal cells. Studies were included for review only if they described the transplantation of the cell substrate into an in-vivo model of traumatic SCI, induced either bluntly or sharply. Using these inclusion criteria, 162 studies were identified and reviewed in detail, emphasizing their behavioral effects (although not limiting the scope of the discussion to behavioral effects alone). Significant differences between cells of the same ''type'' exist based on the species and age of donor, as well as culture conditions and mode of delivery. Many of these studies used cell transplantations in combination with other strategies. The systematic review makes it very apparent that cells derived from rodent sources have been the most extensively studied, while only 19 studies reported the transplantation of human cells, nine of which utilized bone-marrow stromal cells. Similarly, the vast majority of studies have been conducted in rodent models of injury, and few studies have investigated cell transplantation in larger mammals or primates. With respect to the timing of intervention, nearly all of the studies reviewed were conducted with transplantations occurring subacutely and acutely, while chronic treatments were rare and often failed to yield functional benefits.

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Section: Behaviormentioning

confidence: 50%

A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury

Tetzlaff

Okon

Karimi-Abdolrezaee

et al. 2011

Journal of Neurotrauma

480

454

View full text Add to dashboard Cite

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“…Reconstruction of damaged nerves results from different factors that have been investigated by different methods. A number of methods, such as utilizing allograft techniques, cell therapy including Schwann cells, stem cells, fi broblasts, and olfactory cells, or drug therapy, use of biologic tubes, designed scaffolds with synthetic and natural materials and oriented channels, and absorbable and nonabsorbable synthetic and natural polymers with unique features benefi ting from new nanotechnology were studied for improving the performance of strategies to repair damaged nerve tissue (Ghaemmaghami et al, 2009;Firouzi et al, 2006;Ducker & Hayes, 2000). Common grafting in surgery was autograft or nerve removal from elsewhere of the body.…”

Section: Introductionmentioning

confidence: 99%

A nanofibrous PHBV tube with Schwann cell as artificial nerve graft contributing to Rat sciatic nerve regeneration across a 30-mm defect bridge

Biazar

Keshel

2013

Cell Communication & Adhesion

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“…A number of methods, such as allograft techniques, cell therapy including Schwann cells (SCs), stem cells, fi broblasts, and olfactory cells, or drug therapy, use of biologic tubes, designed scaffolds with synthetic and natural materials and oriented channels, as well as absorbable and non-absorbable synthetic and natural polymers with unique features benefi ting from new nanotechnology were studied for improving the performance of strategies to repair damaged nerve tissue (Ghaemmaghami et al, 2009;Firouzi et al, 2006;Williams et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…In the last decade, a variety of cell types, including human neural stem cells (Hughes, 2002), embryonic stem cell derivatives (Burnett & Zager, 2004;Yin et al, 1998), adult bone marrow stromal cells (BMSCs) (Biazar et al, 2010a;Ghaemmaghami et al, 2009;Firouzi et al, 2006) and primary SCs, have been transplanted into the injured nerve to their neuro-regenerative activities. These preclinical studies showed that engrafted stem cells promote substantial functional recovery after nerve injury through both cell-autonomous/cell replacement and paracrine/ trophic effects (Williams et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Behavioral evaluation of regenerated rat sciatic nerve by a nanofibrous PHBV conduit filled with Schwann cells as artificial nerve graft

Biazar

Keshel

Pouya

2013

Cell Communication & Adhesion

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The aim of this study is to develop a nanofi brous polymeric nerve conduit with Schwann cells (SCs) and to evaluate its effi ciency on the promotion of functional and locomotive activities in rats. The conduits were implanted into a 30-mm gap in the sciatic nerves of the rats. Four months after surgery, the rats were monitored and evaluated by behavioral analyses such as toe out angle, toe spreading analysis, walking track analysis, extensor postural thrust, open-fi eld analysis, swimming test and nociceptive function, four months post surgery. Four months post-operatively, the results from behavioral analyses demonstrated that in the grafted groups especially in the grafted group with SCs, the rat sciatic nerve trunk had been reconstructed with functional recovery such as walking, swimming and recovery of nociceptive function. This study proves the feasibility of artifi cial conduit with SCs for nerve regeneration by bridging a longer defect in the rat model.

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Transplantation of Schwann cells to subarachnoid space induces repair in contused rat spinal cord

Cited by 45 publications

References 19 publications

A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury

A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury

A nanofibrous PHBV tube with Schwann cell as artificial nerve graft contributing to Rat sciatic nerve regeneration across a 30-mm defect bridge

Behavioral evaluation of regenerated rat sciatic nerve by a nanofibrous PHBV conduit filled with Schwann cells as artificial nerve graft

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