Transplantation of photobiomodulation-preconditioned diabetic stem cells accelerates ischemic wound healing in diabetic rats

Ahmadi, Houssein; Amini, Abdollah; Fathabady, Fatemeh Fadaei; Mostafavinia, Atarodsadat; Zare, Fatemeh; Ebrahimpour-Malekshah, Roohollah; Ghalibaf, Mustafa Neshat; Abrisham, Matin; Rezaei, Fatemehalsadat; Albright, Richard; Ghoreishi, Seyed Kamran; Chien, Sufan; Bayat, Mohammad

doi:10.1186/s13287-020-01967-2

Cited by 47 publications

(61 citation statements)

References 56 publications

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“…Whereas our hypothesis (combined application of PBM and stem cells can accelerate repairing process and assist healing DFU in animal models and patients) was confirmed through preclinical studies [29,30,31], we suggest further animal and clinical trial investigations be conducted in order to provide more documentation. Hopefully these outcomes would help the use of ADSCs plus PBM as a routine treatment protocol for the healing of severe DFU in patients with DM.…”

Section: Discussionmentioning

confidence: 70%

“…Groups 2-5 displayed significantly increased wound strength compared to group 1.In most cases, group 5 had significantly better results than groups 2, 3, and 4. Ahmadi et al concluded that preconditioning diabetic ADSCs with PBM in vitro plus PBM in vivo significantly accelerated healing in the diabetic rat model of an ischemic infected delayed-healing wound [29]. In other related studies, the same results were reported.…”

Section: How the Combined Application Of Pbm And Adscs Can Accelerate Dfu Healingmentioning

confidence: 64%

“…Preconditioning diabetic ADSC with PBM significantly hastened healing in ischemic MRSA-infected, delayed-healing wounds in rats with type one DM compared to the control, ADSC alone, and ADSC plus PBM-in vivo rats. The combined administration of preconditioned diabetic-ADSC with PBM plus PBM therapy in vivo demonstrated a significantly superior effect compared to other treatment protocols [29].…”

Section: Discussionmentioning

confidence: 93%

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Combined Administration of Stem Cells and Photobiomodulation on Wound Healing in Diabetes

Bayat¹,

Chien²

2022

Recent Advances in Wound Healing

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Wound healing is an active and compound biological course which can be divided into four steps: hemostasis, inflammation, proliferation, and remodeling. Diabetes mellitus induces weakened wound healing by disturbing one or more of the biological functions of these steps. Diabetic foot ulcers result from the simultaneous action of multiple disturbing causes. Mesenchymal stem cells, especially autologous ones, are easily accessible with noninvasive methods and have been shown to provide a regenerative microenvironment at wound sites. Despite current knowledge, major hurdles remain to be overcome in order to achieve effective therapeutic effects. Photobiomodulation is the use of light to reduce pain and inflammation and stimulate healing and the proliferation of stem cells, which would be very useful in increasing stem cell function and in regenerative medicine. The current study analyzes the results of studies using separate and combined administrations of stem cells and photobiomodulation on diabetic wound healing in patients and animal models. We hypothesize that the combined application of photobiomodulation and stem cells will accelerate the repair process and assist the healing of foot ulcers in diabetes mellitus patients.

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Section: Discussionmentioning

confidence: 70%

Section: How the Combined Application Of Pbm And Adscs Can Accelerate Dfu Healingmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 93%

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Combined Administration of Stem Cells and Photobiomodulation on Wound Healing in Diabetes

Bayat¹,

Chien²

2022

Recent Advances in Wound Healing

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“…MSCs, which are found in bone marrow and adipose tissue, have proven useful in wound healing applications. Recently, adipose-derived mesenchymal stem cells preconditioned by photobiomodulation, firstly in vitro and then followed by in vivo, were found to significantly improve healing rates of ischemic infected DFU in a rat model (Ahmadi et al, 2020). MSCs provide a great number of benefits, such as their ability to manage oxidative stress and promote an anti-inflammatory response and formation of new blood vessels in damaged tissues (Becerra-bayona et al, 2020).…”

Section: Stem Cellsmentioning

confidence: 99%

3D scaffolds in the treatment of diabetic foot ulcers: New trends vs conventional approaches

Glover

Stratakos

Váradi

et al. 2021

International Journal of Pharmaceutics

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“…22 Photobiomodulation (PBM), as a treatment strategy, is expected to resolve the weak potential of transplantation and viability of ASC. 29 MSCs and progenitor cells are particularly susceptible to PBM. 30 It has been shown that PBM potentially promotes the proliferation, differentiation, and growth factor secretion of MSCs through altering gene expression and activation.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Treatment of Photobiomodulation and Demineralized Bone Matrix With Adipose-Derived Stem Cells Improve Bone Healing in an osteoporotic bone defect

et al. 2021

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Introduction: The ability of simultaneous treatment of critical-sized femoral defects (CSFDs) with photobiomodulation (PBM) and demineralized bone matrix (DBM) with or without seeded adipose-derived stem cells (ASCs) to induce bone reconstruction in ovariectomized induced osteoporotic (OVX) rats was investigated. Methods: The OVX rats with CSFD were arbitrarily separated into 6 groups: control, scaffold (S, DBM), S + PBM, S + alendronate (ALN), S + ASCs, and S + PBM + ASCs. Each group was assessed by cone beam computed tomography (CBCT) and histological examinations. Results: In the fourth week, CBCT and histological analyses revealed that the largest volume of new bone formed in the S + PBM and S + PBM + ASC groups. The S + PBM treatment relative to the S and S + ALN treatments remarkably reduced the CSFD (Mann-Whitney test, P = 0.009 and P = 0.01). Furthermore, S + PBM + ASCs treatment compared to the S and S + ALN treatments significantly decreased CSFD (Mann Whitney test, P = 0.01). In the eighth week, CBCT analysis showed that extremely enhanced bone regeneration occurred in the CSFD of the S + PBM group. Moreover, the CSFD in the S + PBM group was substantially smaller than S, S + ALN and S + ASCs groups (Mann Whitney test, P = 0.01, P = 0.02 and P = 0.009). Histological observations showed more new bone formation in the treated CSFD of S + PBM + ASCs and S + PBM groups. Conclusion: The PBM plus DBM with or without ASCs significantly enhanced bone healing in the CSFD in OVX rats compared to control, DBM alone, and ALN plus DBM groups. The PBM plus DBM with or without ASCs significantly decreased the CSFD area compared to either the solo DBM or ALN plus DBM treatments.

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Transplantation of photobiomodulation-preconditioned diabetic stem cells accelerates ischemic wound healing in diabetic rats

Cited by 47 publications

References 56 publications

Combined Administration of Stem Cells and Photobiomodulation on Wound Healing in Diabetes

Combined Administration of Stem Cells and Photobiomodulation on Wound Healing in Diabetes

3D scaffolds in the treatment of diabetic foot ulcers: New trends vs conventional approaches

Simultaneous Treatment of Photobiomodulation and Demineralized Bone Matrix With Adipose-Derived Stem Cells Improve Bone Healing in an osteoporotic bone defect

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