Transplantation of olfactory ensheathing cells or Schwann cells restores rapid and secure conduction across the transected spinal cord

Imaizumi, Toshio; Lankford, Karen L.; Kocsis, Jeffery D.

doi:10.1016/s0006-8993(99)02285-4

Cited by 193 publications

(139 citation statements)

References 16 publications

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“…Their transplantation into the CNS resulted in production of compact myelin [223,224] and restoration of normal conduction velocity in the dorsal columns of the spinal cord, predicting functional recovery [221,[225][226][227][228]. They can be isolated from a sural nerve biopsy, expanded in culture, and eventually delivered as an autologous graft to a demyelinated focus in the CNS.…”

Section: Schwann Cellsmentioning

confidence: 99%

“…These cells are unique in that they continue to arise in the olfactory epithelium from which they can migrate to the olfactory bulb throughout life [232][233][234]. Rodent and human OECs generate Schwann-cell-like myelin and improve conduction properties when transplanted to areas of demyelination in the brain or spinal cord [227,233,[235][236][237][238][239][240]. OECs also have the capacity to promote axonal growth [241] and to secrete neurotrophic molecules [242,243].…”

Section: Olfactory Nerve Ensheathing Cellsmentioning

confidence: 99%

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Cell Therapy for Multiple Sclerosis

Ben‐Hur

2011

Neurotherapeutics

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The spontaneous recovery observed in the early stages of multiple sclerosis (MS) is substituted with a later progressive course and failure of endogenous processes of repair and remyelination. Although this is the basic rationale for cell therapy, it is not clear yet to what degree the MS brain is amenable for repair and whether cell therapy has an advantage in comparison to other strategies to enhance endogenous remyelination. Central to the promise of stem cell therapy is the therapeutic plasticity, by which neural precursors can replace damaged oligodendrocytes and myelin, and also effectively attenuate the autoimmune process in a local, nonsystemic manner to protect brain cells from further injury, as well as facilitate the intrinsic capacity of the brain for recovery. These fundamental immunomodulatory and neurotrophic properties are shared by stem cells of different sources. By using different routes of delivery, cells may target both affected white matter tracts and the perivascular niche where the trafficking of immune cells occur. It is unclear yet whether the therapeutic properties of transplanted cells are maintained with the duration of time. The application of neural stem cell therapy (derived from fetal brain or from human embryonic stem cells) will be realized once their purification, mass generation, and safety are guaranteed. However, previous clinical experience with bone marrow stromal (mesenchymal) stem cells and the relative easy expansion of autologous cells have opened the way to their experimental application in MS. An initial clinical trial has established the probable safety of their intravenous and intrathecal delivery. Short-term follow-up observed immunomodulatory effects and clinical benefit justifying further clinical trials.

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Section: Schwann Cellsmentioning

confidence: 99%

Section: Olfactory Nerve Ensheathing Cellsmentioning

confidence: 99%

Cell Therapy for Multiple Sclerosis

Ben‐Hur

2011

Neurotherapeutics

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“…Olfactory ensheathing cells (OECs) elicit remyelination of demyelinated spinal axons Kato et al, 2000), restore central nerve conduction (Imaizumi et al, 1998(Imaizumi et al, , 2000, and promote axonal regeneration (Li et al, 1998;Imaizumi et al, 2000;Ramón-Cueto et al, 2000;Lu et al, , 2002 after transplantation in lesioned spinal cords. Significant recovery of motor and sensory functions was reported in OECs-transplanted rats compared with DMEM-injected animals after complete spinal cord transection (Ramón-Cueto et al, 2000;Lu et al, , 2002.…”

Section: Introductionmentioning

confidence: 99%

Olfactory ensheathing cells transplanted in lesioned spinal cord prevent loss of spinal cord parenchyma and promote functional recovery

Verdú

García-Alías

Forés

et al. 2003

Glia

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We studied the effects of olfactory ensheathing cells (OECs) transplanted in a photochemical spinal cord injury in adult rats. After dorsal laminectomy at T8 vertebra, subjacent spinal cord was bathed with rose Bengal for 10 min and illuminated with visible light by means of an optic fiber connected to a halogen lamp for 2.5 min at maximal intensity of 8 kLux. Eight injured rats received a suspension of OECs in DMEM, and another eight rats received DMEM alone. Locomotor ability scored by the BBB scale, pain sensibility by the plantar algesimetry test, and motor-and somatosensory-evoked potentials by electrophysiological techniques were evaluated for 3 months postsurgery. Finally, all rats were perfused with paraformaldehyde and transverse sections from the spinal cord segment at the lesion site were immunostained against GFAP. Area of the preserved spinal cord parenchyma was measured from the GFAPimmunolabeled cord sections. The BBB score and the amplitude of motor-and somatosensory-evoked potentials were higher in OECs-transplanted rats than in DMEMinjected animals throughout follow-up, whereas the withdrawal response to heat noxious stimulus was lower in OEC-than in DMEM-injected rats. The area of preserved spinal cord was significantly larger in OECs-transplanted rats than in DMEM-injected animals. These results indicate that OECs promote functional and morphological preservation of the spinal cord after photochemical injury. GLIA 42:275-286, 2003.

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“…Una de las ventajas de la terapia mediante trasplante de GE es que sus efectos no se limitan a la zona del trasplante, pues dicha glía tiene una alta capacidad de migración a través de la médula espinal lesionada 14,15 . Los estudios experimentales previos en los que se ha trasplantado GE son contradictorios, pues hay investigadores que indican que en los animales trasplantados existe mayor recuperación funcional respecto a animales sin trasplante o con trasplante de vehículo 14,[16][17][18] , mientras que otros investigadores no obtienen diferencias 19 . Sin embargo, en los animales trasplantados con GE se reduce la cavitación 11,14,20 y aumenta el número de fibras regenerativas a través de la lesión 18,20 .…”

Section: Figura 1 Secciones Transversales De La Médula Espinal Inmununclassified

El trasplante de células de la glía envolvente del bulbo olfatorio tras lesión de la médula espinal: Estudio experimental en ratas

García-Alías

López-Vales

Verdú

et al. 2005

Revista de Ortopedia y Traumatología

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Transplantation of olfactory ensheathing cells or Schwann cells restores rapid and secure conduction across the transected spinal cord

Cited by 193 publications

References 16 publications

Cell Therapy for Multiple Sclerosis

Cell Therapy for Multiple Sclerosis

Olfactory ensheathing cells transplanted in lesioned spinal cord prevent loss of spinal cord parenchyma and promote functional recovery

El trasplante de células de la glía envolvente del bulbo olfatorio tras lesión de la médula espinal: Estudio experimental en ratas

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